Sex differences in 1-year clinical outcomes after percutaneous coronary intervention with COMBO stents: From the COMBO collaboration

the MASCOT and REMEDEE investigators (full list of collaborators shown in the Appendix)

Research output: Contribution to journalArticle

Abstract

Background: The COMBO drug eluting stent is a novel device with luminal endothelial progenitor cell capture technology for rapid homogeneous endothelialization. Methods and results: We examined for sex differences in 1-year outcomes after COMBO stenting from the COMBO collaboration, a pooled patient-level dataset from the MASCOT and REMEDEE multicenter registries. The primary endpoint was 1-year target lesion failure (TLF), composite of cardiac death, target vessel-myocardial infarction (TV-MI), or clinically driven target lesion revascularization (CD-TLR). Secondary outcomes included stent thrombosis (ST). Adjusted outcomes were assessed using Cox regression methods. The study included 861 (23.8%) women and 2,753 (76.2%) men. Women were older with higher prevalence of several comorbidities including diabetes mellitus. Risk of 1-year TLF was similar in both sexes (3.8% vs. 3.9%, HR 0.92, 95% CI 0.59–1.42, p =.70), without sex differences in the incidence of cardiac death (1.6% vs. 1.5%, p =.78), TV-MI (1.5% vs. 1.1%, p =.32), or CD-TLR (2.0% vs. 2.2%, p =.67). Definite or probable ST occurred in 0.4% women and 1.0% men (HR 0.26, 95% CI 0.06–1.11, p =.069). Conclusions: Despite greater clinical risks at baseline, women treated with COMBO stents had similarly low 1-year TLF and other ischemic outcomes compared to men.

Original languageEnglish
JournalCatheterization and Cardiovascular Interventions
DOIs
Publication statusAccepted/In press - 1 Jan 2020

Keywords

  • anti-CD34 antibodies
  • dual therapy stent
  • endothelial progenitor cell capture
  • percutaneous coronary intervention
  • sex differences

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