Sex Determination by Epigenetic Regulation

Muhammad Garry Syahrizal Hanafi, Elza Ibrahim Auerkari, Ken Sekar Langit, Ria Puspitawati

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

The process of forming sex in the fetal phase involves many complexes and genes. The gene that plays the most important role in gender formation is the SRY gene or usually called the Sex Determining Y gene. However, the role of epigenetic regulation is beginning to be discovered concerning the determination of human gonads. Epigenetic regulation is the process of gene expression or phenotypic changes in an individual caused by non-genetic factors without changes in the basic DNA sequence. Epigenetic mechanisms enable organisms to integrate genomic and environmental information to change gene activity and produce a specific phenotype. Changes in gene expression allow cells to specialize and keep their identity during development. This is critical for determining gender. In addition, epigenetics can also contribute to several disorders of sexual development. These findings encourage further research to develop sex determination techniques through epigenetic analysis.

Original languageEnglish
Title of host publication6th Biomedical Engineering''s Recent Progress in Biomaterials, Drugs Development, and Medical Devices
Subtitle of host publicationProceedings of the 6th International Symposium of Biomedical Engineering, ISBE 2021
EditorsSiti Fauziyah Rahman, Ahmad Zakiyuddin, Yudan Whulanza, Nurul Intan
PublisherAmerican Institute of Physics Inc.
ISBN (Electronic)9780735443716
DOIs
Publication statusPublished - 16 Aug 2022
Event6th International Symposium of Biomedical Engineering''s Recent Progress in Biomaterials, Drugs Development, and Medical Devices, ISBE 2021 - Depok, Virtual, Indonesia
Duration: 7 Jul 20218 Jul 2021

Publication series

NameAIP Conference Proceedings
Volume2537
ISSN (Print)0094-243X
ISSN (Electronic)1551-7616

Conference

Conference6th International Symposium of Biomedical Engineering''s Recent Progress in Biomaterials, Drugs Development, and Medical Devices, ISBE 2021
Country/TerritoryIndonesia
CityDepok, Virtual
Period7/07/218/07/21

Keywords

  • Epigenetic
  • Epigenetic Regulation
  • Forensic
  • Sex Determination

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