TY - JOUR
T1 - Serological Evidence of Japanese Encephalitis Virus Circulation in Asian Children From Dengue-Endemic Countries
AU - Nealon, Joshua
AU - Taurel, Anne Frieda
AU - Yoksan, Sutee
AU - Moureau, Annick
AU - Bonaparte, Matt
AU - Quang, Luong Chan
AU - Capeding, Maria R.
AU - Hadinegoro, Sri Rezeki
AU - Chansinghakul, Danaya
AU - Bouckenooghe, Alain
AU - PRAYITNO, ARI
N1 - Publisher Copyright:
© 2018 The Author(s).
PY - 2019/1/9
Y1 - 2019/1/9
N2 - Background. Japanese encephalitis virus (JEV) is a zoonotic, mosquito-borne flavivirus, distributed across Asia. Infections are mostly mild or asymptomatic, but symptoms include neurological disorders, sequelae, and fatalities. Data to inform control strategies are limited due to incomplete case reporting. Methods. We used JEV serological data from a multicountry Asian dengue vaccine study in children aged 2-14 years to describe JEV endemicity, measuring antibodies by plaque reduction neutralization test (PRNT50). Results. A total 1479 unvaccinated subjects were included. A minimal estimate of pediatric JEV seroprevalence in dengue-naive individuals was 8.1% in Indonesia, 5.8% in Malaysia, 10.8% in the Philippines, and 30.7% in Vietnam, translating to annual infection risks varying from 0.8% (in Malaysia) to 5.2% (in Vietnam). JEV seroprevalence and annual infection estimates were much higher in children with history of dengue infection, indicating cross-neutralization within the JEV PRNT50 assay. Conclusions. These data confirm JEV transmission across predominantly urban areas and support a greater emphasis on JEV case finding, diagnosis, and prevention.
AB - Background. Japanese encephalitis virus (JEV) is a zoonotic, mosquito-borne flavivirus, distributed across Asia. Infections are mostly mild or asymptomatic, but symptoms include neurological disorders, sequelae, and fatalities. Data to inform control strategies are limited due to incomplete case reporting. Methods. We used JEV serological data from a multicountry Asian dengue vaccine study in children aged 2-14 years to describe JEV endemicity, measuring antibodies by plaque reduction neutralization test (PRNT50). Results. A total 1479 unvaccinated subjects were included. A minimal estimate of pediatric JEV seroprevalence in dengue-naive individuals was 8.1% in Indonesia, 5.8% in Malaysia, 10.8% in the Philippines, and 30.7% in Vietnam, translating to annual infection risks varying from 0.8% (in Malaysia) to 5.2% (in Vietnam). JEV seroprevalence and annual infection estimates were much higher in children with history of dengue infection, indicating cross-neutralization within the JEV PRNT50 assay. Conclusions. These data confirm JEV transmission across predominantly urban areas and support a greater emphasis on JEV case finding, diagnosis, and prevention.
KW - Japanese
KW - encephalitis
KW - epidemiology
KW - flavivirus
KW - seroepidemiologic studies
UR - http://www.scopus.com/inward/record.url?scp=85059794953&partnerID=8YFLogxK
U2 - 10.1093/infdis/jiy513
DO - 10.1093/infdis/jiy513
M3 - Article
C2 - 30165664
AN - SCOPUS:85059794953
SN - 0022-1899
VL - 219
SP - 375
EP - 381
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
IS - 3
ER -