Sequence and temperature effect on electrical properties of modified poly(dA)-poly(dT) DNA wire

Daniel K. Suhendro, Efta Yudiarsah, Rosari Saleh

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Citation (Scopus)

Abstract

We studied the effect of thermal fluctuations on charge transport in two types of modified poly(dA)-poly(dT) DNA by calculating the transmission probability and I-V characteristics. The modification is carried out by replacing some of the AT base pairs with CG or GC base pairs placed randomly along the chain. The DNA model is placed in between two metallic electrodes. We used tight binding Hamiltonian to model the DNA molecule and electrodes. The thermal fluctuation is modeled by varying the twist angles of each base in the DNA. The transfer matrix and scattering matrix methods were employed in calculating the transmission probability. Transmission probability is used as an input in calculating I-V characteristics using Landauer-Büttiker formalism. The twist angle disorder is influenced by the temperature and frequency. In order to prevent spurious results, we take the average value transmission probability of 1000 realizations of twist angles. Our results indicate that the DNA modified by CG base pairs has its electrical properties impeded by increasing thermal fluctuation (increasing temperature and decreasing frequency). However, different behavior is observed on the DNA modified by GC base pairs, at low temperature its electrical properties are enhanced by decreasing frequency. Moreover, electrical properties of this DNA at high frequency are also enhanced as temperature increases.

Original languageEnglish
Title of host publication4th International Conference on Theoretical and Applied Physics, ICTAP 2014
EditorsNi Nyoman Rupiasih, Wayan Gede Suharta, Hery Suyanto
PublisherAmerican Institute of Physics Inc.
ISBN (Electronic)9780735413665
DOIs
Publication statusPublished - 11 Mar 2016
Event4th International Conference on Theoretical and Applied Physics, ICTAP 2014 - Bali, Indonesia
Duration: 16 Oct 201417 Oct 2014

Publication series

NameAIP Conference Proceedings
Volume1719
ISSN (Print)0094-243X
ISSN (Electronic)1551-7616

Conference

Conference4th International Conference on Theoretical and Applied Physics, ICTAP 2014
CountryIndonesia
CityBali
Period16/10/1417/10/14

Keywords

  • DNA
  • Electrical properties
  • sequence disorder
  • thermal fluctuation
  • transmission

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