Sepsis-induced T-cell suppression in pediatric sepsis

Antonius Hocky Pudjiadi

Sepsis-induced T-cell suppression in pediatric sepsis

Department of Pediatric

Research output: Contribution to journal › Review article › peer-review

Abstract

Sepsis contributes to significant mortality and morbidity in children. Despite rigorous resusci-tation effort, adequate antibiotics and advanced medical support, a significant proportion still face mortality due to multiple organ failure. Re-. cent hypothesis suggests host’s immune response pathology in the form of compensatory anti-in-flammatory response syndrome (CARS). This review aims to elucidate the pathophysiology of immune paralysis, both affecting innate and acquired immunity.

Original language	English
Pages (from-to)	172-180
Number of pages	9
Journal	Critical Care and Shock
Volume	2021
Issue number	July
Publication status	Published - 2021

Keywords

Compensatory anti-inflammatory response syndrome
HLA-DR
Immunoparalysis
Sepsis
TNF-α

Cite this

@article{8ac5889a2997449fbd53df7775a1971f,

title = "Sepsis-induced T-cell suppression in pediatric sepsis",

abstract = "Sepsis contributes to significant mortality and morbidity in children. Despite rigorous resusci-tation effort, adequate antibiotics and advanced medical support, a significant proportion still face mortality due to multiple organ failure. Re-. cent hypothesis suggests host{\textquoteright}s immune response pathology in the form of compensatory anti-in-flammatory response syndrome (CARS). This review aims to elucidate the pathophysiology of immune paralysis, both affecting innate and acquired immunity.",

keywords = "Compensatory anti-inflammatory response syndrome, HLA-DR, Immunoparalysis, Sepsis, TNF-α",

author = "Pudjiadi, {Antonius Hocky}",

note = "Funding Information: The author would like to acknowledge Fatima Sa-fira Alatas, MD, PhD, Raditya Dewangga, MD, and Stephanie Wijaya, MD, MRes. for their help in lan-guage editing and proofreading the article, and illus-tration for figures used in this article. The author would also like to thank the whole staff of Department of Child Health of Faculty of Medicine, Universitas Indonesia for their support. Publisher Copyright: {\textcopyright} 2021, The Indonesian Foundation of Critical Care Medicine. All rights reserved.",

year = "2021",

language = "English",

volume = "2021",

pages = "172--180",

journal = "Critical Care and Shock",

issn = "1410-7767",

publisher = "Indonesian Society of Critical Care Medicine",

number = "July",

}

TY - JOUR

T1 - Sepsis-induced T-cell suppression in pediatric sepsis

AU - Pudjiadi, Antonius Hocky

N1 - Funding Information: The author would like to acknowledge Fatima Sa-fira Alatas, MD, PhD, Raditya Dewangga, MD, and Stephanie Wijaya, MD, MRes. for their help in lan-guage editing and proofreading the article, and illus-tration for figures used in this article. The author would also like to thank the whole staff of Department of Child Health of Faculty of Medicine, Universitas Indonesia for their support. Publisher Copyright: © 2021, The Indonesian Foundation of Critical Care Medicine. All rights reserved.

PY - 2021

Y1 - 2021

N2 - Sepsis contributes to significant mortality and morbidity in children. Despite rigorous resusci-tation effort, adequate antibiotics and advanced medical support, a significant proportion still face mortality due to multiple organ failure. Re-. cent hypothesis suggests host’s immune response pathology in the form of compensatory anti-in-flammatory response syndrome (CARS). This review aims to elucidate the pathophysiology of immune paralysis, both affecting innate and acquired immunity.

AB - Sepsis contributes to significant mortality and morbidity in children. Despite rigorous resusci-tation effort, adequate antibiotics and advanced medical support, a significant proportion still face mortality due to multiple organ failure. Re-. cent hypothesis suggests host’s immune response pathology in the form of compensatory anti-in-flammatory response syndrome (CARS). This review aims to elucidate the pathophysiology of immune paralysis, both affecting innate and acquired immunity.

KW - Compensatory anti-inflammatory response syndrome

KW - HLA-DR

KW - Immunoparalysis

KW - Sepsis

KW - TNF-α

UR - http://www.scopus.com/inward/record.url?scp=85112603065&partnerID=8YFLogxK

M3 - Review article

AN - SCOPUS:85112603065

SN - 1410-7767

VL - 2021

SP - 172

EP - 180

JO - Critical Care and Shock

JF - Critical Care and Shock

IS - July

ER -

Sepsis-induced T-cell suppression in pediatric sepsis

Abstract

Keywords

Other files and links

Fingerprint

Cite this