Sepsis-induced T-cell suppression in pediatric sepsis

Research output: Contribution to journalReview articlepeer-review


Sepsis contributes to significant mortality and morbidity in children. Despite rigorous resusci-tation effort, adequate antibiotics and advanced medical support, a significant proportion still face mortality due to multiple organ failure. Re-. cent hypothesis suggests host’s immune response pathology in the form of compensatory anti-in-flammatory response syndrome (CARS). This review aims to elucidate the pathophysiology of immune paralysis, both affecting innate and acquired immunity.

Original languageEnglish
Pages (from-to)172-180
Number of pages9
JournalCritical Care and Shock
Issue numberJuly
Publication statusPublished - 2021


  • Compensatory anti-inflammatory response syndrome
  • HLA-DR
  • Immunoparalysis
  • Sepsis
  • TNF-α


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