SEMA3B but not CUL 1 as marker for pre-eclampsia progression

Tjam Diana Samara, Isabella Kurnia Liem, Ani Retno Prijanti, Abdul Hamid Andrijono

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)


Background: An imbalance between pro- and anti-angiogenic factors contributes to impaired trophoblast invasion during pregnancy, leading to failure of uterine spiral artery remodeling, blood vessel ischemia, and pre-eclampsia (PE). Anti-angiogenic semaphorin 3B (SEMA3B) and pro-angiogenic cullin 1 (CUL 1 ) are expressed in both the placenta and maternal blood. The present study investigated correlations between serum and placental SEMA3B as well as CUL 1 levels in late-onset PE. Methods: This cross-sectional study included 50 patients with late-onset (≥ 32 weeks gestation) PE. Maternal serum was obtained before delivery, and placentas were obtained immediately after delivery. SEMA3B and CUL 1 levels were evaluated by ELISA. Results were statistically analysed by Spearman correlation test, with a P < 0.05 considered statistically significant. Results: While elevated serum SEMA3B levels significantly correlated with increased placental SEMA3B levels in late-onset PE (R = 0.620, P = 0.000), alteration of serum CUL 1 levels did not correlate with alteration of placental CUL 1 . Conclusion: Alteration of circulating maternal SEMA3B, but not CUL 1 , levels can potentially be used to monitor PE progression during pregnancy.

Original languageEnglish
Pages (from-to)66-72
Number of pages7
JournalMalaysian Journal of Medical Sciences
Issue number1
Publication statusPublished - 1 Jan 2019


  • Cullin 1
  • Placenta
  • Pre-eclampsia
  • Semaphorin 3B
  • Serum


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