Self-Assembly and Hydrogelation of Peptide Amphiphiles

Irwansyah, Riwandi Sihombing, Wahyudi Priyono Suwarso

Research output: Contribution to journalArticlepeer-review


Seven peptide amphiphiles were successfully synthesized using solid phase peptide synthesis method. Peptide amphiphiles were characterized using matrix assisted laser desorption/ionization (MALDI). Atomic force microscopy (AFM) study showed that peptide amphiphiles having glycine, valine, or proline as linker, self-assembled into 100-200 nm nanofibers structure. According to our research, both peptide amphiphile with positive and negative charges bear similar self-assembly properties. Peptide amphiphile also showed its capability as low molecular weight gelator (LMWG). Peptide amphiphiles bearing C-16 and C-12 as alkyl showed better hydrogelation properties than C-8 alkyl. Five out of seven peptide amphiphiles have minimum gelation concentration (MGC) lower than 1%(w/v).

Original languageEnglish
JournalMAKARA of Science Series
Issue number1
Publication statusPublished - 2012


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