TY - JOUR
T1 - Secondary metabolites from Garcinia daedalanthera Pierre leaves (Clusiaceae)
AU - Forestrania, Roshamur Cahyan
AU - Anaya-Eugenio, Gerardo D.
AU - Acuña, U. M.
AU - Ren, Yulin
AU - Elya, Berna
AU - de Blanco, Esperanza Carcache
N1 - Funding Information:
This study was supported by the College of Pharmacy, Ohio State University, and the Endowment Funds for Education (LPDP), Jakarta, Indonesia. The authors would like to acknowledge Dr. Craig McElroy, College of Pharmacy, Ohio State University, for support in the use of spectroscopic instruments.
Publisher Copyright:
© 2020 Informa UK Limited, trading as Taylor & Francis Group.
PY - 2021
Y1 - 2021
N2 - Two new glycerol esters, (S)-2-hydroxy-3-(octanoyloxy)propyl tetracosanoate (1) and (S)-3-(((S)-11-acetoxy octadecanoyl)oxy)propane-1,2-diyl diacetate (2), and eight known compounds, docosanedioic acid (3), 2,5-dimethylnonadecane (4), lupeol (5), stigmasterol (6), β-sitosterol (7), heptadecanoic acid (8), hexanedioic acid, 1,6-bis[(2R)-ethylhexyl] ester (9), and 1,3-di-O-[2’,2’-di-(p-phenylene)] (10) were isolated from the leaves of Garcinia daedalanthera Pierre, collected from Indonesia. Structural analysis of the isolates was performed using 1D- and 2D-NMR, LC- and GC-MS, IR, polarimetry, and UV-visible spectroscopic methods. Cytotoxicity assessments, as well as reactive oxygen species (ROS) analysis of the isolates, were also completed. Lupeol was the only compound found active with an IC50 value of 19.2µM against HT-29 colon cancer cells. Significant ROS inhibition and induction activity was observed for compounds 4 and 8, respectively.
AB - Two new glycerol esters, (S)-2-hydroxy-3-(octanoyloxy)propyl tetracosanoate (1) and (S)-3-(((S)-11-acetoxy octadecanoyl)oxy)propane-1,2-diyl diacetate (2), and eight known compounds, docosanedioic acid (3), 2,5-dimethylnonadecane (4), lupeol (5), stigmasterol (6), β-sitosterol (7), heptadecanoic acid (8), hexanedioic acid, 1,6-bis[(2R)-ethylhexyl] ester (9), and 1,3-di-O-[2’,2’-di-(p-phenylene)] (10) were isolated from the leaves of Garcinia daedalanthera Pierre, collected from Indonesia. Structural analysis of the isolates was performed using 1D- and 2D-NMR, LC- and GC-MS, IR, polarimetry, and UV-visible spectroscopic methods. Cytotoxicity assessments, as well as reactive oxygen species (ROS) analysis of the isolates, were also completed. Lupeol was the only compound found active with an IC50 value of 19.2µM against HT-29 colon cancer cells. Significant ROS inhibition and induction activity was observed for compounds 4 and 8, respectively.
KW - cytotoxicity
KW - fatty acid
KW - Garcinia daedalanthera
KW - glycerol ester
KW - reactive oxygen species
KW - spectroscopic analysis
UR - http://www.scopus.com/inward/record.url?scp=85087115842&partnerID=8YFLogxK
U2 - 10.1080/14786419.2020.1777117
DO - 10.1080/14786419.2020.1777117
M3 - Article
C2 - 32530310
AN - SCOPUS:85087115842
SN - 1478-6419
VL - 36
SP - 207
EP - 213
JO - Natural Product Research
JF - Natural Product Research
IS - 1
ER -
