Secondary metabolites from Garcinia daedalanthera Pierre leaves (Clusiaceae)

Roshamur Cahyan Forestrania, Gerardo D. Anaya-Eugenio, U. M. Acuña, Yulin Ren, Berna Elya, Esperanza Carcache de Blanco

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

Two new glycerol esters, (S)-2-hydroxy-3-(octanoyloxy)propyl tetracosanoate (1) and (S)-3-(((S)-11-acetoxy octadecanoyl)oxy)propane-1,2-diyl diacetate (2), and eight known compounds, docosanedioic acid (3), 2,5-dimethylnonadecane (4), lupeol (5), stigmasterol (6), β-sitosterol (7), heptadecanoic acid (8), hexanedioic acid, 1,6-bis[(2R)-ethylhexyl] ester (9), and 1,3-di-O-[2’,2’-di-(p-phenylene)] (10) were isolated from the leaves of Garcinia daedalanthera Pierre, collected from Indonesia. Structural analysis of the isolates was performed using 1D- and 2D-NMR, LC- and GC-MS, IR, polarimetry, and UV-visible spectroscopic methods. Cytotoxicity assessments, as well as reactive oxygen species (ROS) analysis of the isolates, were also completed. Lupeol was the only compound found active with an IC50 value of 19.2µM against HT-29 colon cancer cells. Significant ROS inhibition and induction activity was observed for compounds 4 and 8, respectively.

Original languageEnglish
Pages (from-to)207-213
Number of pages7
JournalNatural Product Research
Volume36
Issue number1
DOIs
Publication statusPublished - 2021

Keywords

  • cytotoxicity
  • fatty acid
  • Garcinia daedalanthera
  • glycerol ester
  • reactive oxygen species
  • spectroscopic analysis

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