Secondary metabolites from Garcinia daedalanthera Pierre leaves (Clusiaceae)

Roshamur Cahyan Forestrania, Gerardo D. Anaya-Eugenio, U. M. Acuña, Yulin Ren, Berna Elya, Esperanza Carcache de Blanco

Research output: Contribution to journalArticle

Abstract

Two new glycerol esters, (S)-2-hydroxy-3-(octanoyloxy)propyl tetracosanoate (1) and (S)-3-(((S)-11-acetoxy octadecanoyl)oxy)propane-1,2-diyl diacetate (2), and eight known compounds, docosanedioic acid (3), 2,5-dimethylnonadecane (4), lupeol (5), stigmasterol (6), β-sitosterol (7), heptadecanoic acid (8), hexanedioic acid, 1,6-bis[(2R)-ethylhexyl] ester (9), and 1,3-di-O-[2’,2’-di-(p-phenylene)] (10) were isolated from the leaves of Garcinia daedalanthera Pierre, collected from Indonesia. Structural analysis of the isolates was performed using 1D- and 2D-NMR, LC- and GC-MS, IR, polarimetry, and UV-visible spectroscopic methods. Cytotoxicity assessments, as well as reactive oxygen species (ROS) analysis of the isolates, were also completed. Lupeol was the only compound found active with an IC50 value of 19.2µM against HT-29 colon cancer cells. Significant ROS inhibition and induction activity was observed for compounds 4 and 8, respectively.

Original languageEnglish
JournalNatural Product Research
DOIs
Publication statusAccepted/In press - 2020

Keywords

  • cytotoxicity
  • fatty acid
  • Garcinia daedalanthera
  • glycerol ester
  • reactive oxygen species
  • spectroscopic analysis

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    Forestrania, R. C., Anaya-Eugenio, G. D., Acuña, U. M., Ren, Y., Elya, B., & de Blanco, E. C. (Accepted/In press). Secondary metabolites from Garcinia daedalanthera Pierre leaves (Clusiaceae). Natural Product Research. https://doi.org/10.1080/14786419.2020.1777117