Investigation bioactive secondary metabolite previously, Research Center for Marine and Fisheries Product Processing and Biotechnology found anticancer properties to Emericella nidulans marine fungi strain MFW39 isolated from ascidia Aplidium longithorax collected from Wakatobi Marine National Park. Emestrin was a compound with an ETP (epipolithiodioxopiperazine) group that found in Emericella nidulans marine fungi have cytotoxicity properties. Emestrin show cytotoxic activity to breast cancer cell line [T47D], cancer cervic cell line [HeLa], colon cancer cell line [WiDr] and liver cancer cell line (HepG2). The aim of the research to investigated other derivative of emestrin compound. The screening with UPLC (Ultra Performance Liquid Chromatography) mass analysis q-TOF/MS (quadrupole-Time of Flight/Mass spectra) positif mode (ES+).. Monoisotopic ion Derivative compound of emestrin that detected from (ES+) UPLC-ESI-qTOF-MS spectrum are emestrin B, emestrin C. Another compound that detected are cytochalasin B dan C.
|Journal||EduChemia : Jurnal Kimia dan Pendidikan|
|Publication status||Published - 2016|