Screening of α-glucosidase inhibitory activity from some plants of Apocynaceae, Clusiaceae, Euphorbiaceae, and Rubiaceae

Berna Elya, Katrin, Abdul Mun'im, Wulan Yuliastuti, Anastasia Bangun, Eva Kurnia Septiana

Research output: Contribution to journalArticle

52 Citations (Scopus)

Abstract

Diabetes mellitus (DM) is recognized as a serious global health problem that is characterized by high blood sugar levels. Type 2DM is more common in diabetic populations. In this type of DM, inhibition of -glucosidase is a useful treatment to delay the absorption of glucose after meals. As a megabiodiversity country, Indonesia still has a lot of potential unexploited forests to be developed as a medicine source, including as the -glucosidase inhibitor. In this study, we determine the -glucosidase inhibitory activity of 80 ethanol extracts of leaves and twigs of some plants from the Apocynaceae, Clusiaceae, Euphorbiaceae, and Rubiaceae. Inhibitory activity test of the -glucosidase was performed in vitro using spectrophotometric methods. Compared with the control acarbose (IC 50 117.20μg/mL), thirty-seven samples of forty-five were shown to be more potent α-glucosidase inhibitors with IC 50 values in the range 2.33112.02μg/mL.

Original languageEnglish
Article number281078
JournalJournal of Biomedicine and Biotechnology
Volume2012
DOIs
Publication statusPublished - 12 Jan 2012

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