TY - JOUR
T1 - Screening of α-glucosidase inhibitory activity from some plants of Apocynaceae, Clusiaceae, Euphorbiaceae, and Rubiaceae
AU - Elya, Berna
AU - Basah, Katrin
AU - Mun'Im, Abdul
AU - Yuliastuti, Wulan
AU - Bangun, Anastasia
AU - Septiana, Eva Kurnia
PY - 2012
Y1 - 2012
N2 - Diabetes mellitus (DM) is recognized as a serious global health problem that is characterized by high blood sugar levels. Type 2DM is more common in diabetic populations. In this type of DM, inhibition of -glucosidase is a useful treatment to delay the absorption of glucose after meals. As a megabiodiversity country, Indonesia still has a lot of potential unexploited forests to be developed as a medicine source, including as the -glucosidase inhibitor. In this study, we determine the -glucosidase inhibitory activity of 80 ethanol extracts of leaves and twigs of some plants from the Apocynaceae, Clusiaceae, Euphorbiaceae, and Rubiaceae. Inhibitory activity test of the -glucosidase was performed in vitro using spectrophotometric methods. Compared with the control acarbose (IC 50 117.20μg/mL), thirty-seven samples of forty-five were shown to be more potent α-glucosidase inhibitors with IC 50 values in the range 2.33112.02μg/mL.
AB - Diabetes mellitus (DM) is recognized as a serious global health problem that is characterized by high blood sugar levels. Type 2DM is more common in diabetic populations. In this type of DM, inhibition of -glucosidase is a useful treatment to delay the absorption of glucose after meals. As a megabiodiversity country, Indonesia still has a lot of potential unexploited forests to be developed as a medicine source, including as the -glucosidase inhibitor. In this study, we determine the -glucosidase inhibitory activity of 80 ethanol extracts of leaves and twigs of some plants from the Apocynaceae, Clusiaceae, Euphorbiaceae, and Rubiaceae. Inhibitory activity test of the -glucosidase was performed in vitro using spectrophotometric methods. Compared with the control acarbose (IC 50 117.20μg/mL), thirty-seven samples of forty-five were shown to be more potent α-glucosidase inhibitors with IC 50 values in the range 2.33112.02μg/mL.
UR - http://www.scopus.com/inward/record.url?scp=84855552218&partnerID=8YFLogxK
U2 - 10.1155/2012/281078
DO - 10.1155/2012/281078
M3 - Article
C2 - 22187534
AN - SCOPUS:84855552218
SN - 1110-7243
VL - 2012
JO - Journal of Biomedicine and Biotechnology
JF - Journal of Biomedicine and Biotechnology
M1 - 281078
ER -