Scopoletin, a coumarin derivative compound isolated from Macaranga gigantifolia Merr

Akhmad Darmawan; Soleh Kosela; Leonardus B.S. Kardono; Yana M. Syah

doi:10.7324/JAPS.2012.21231

Scopoletin, a coumarin derivative compound isolated from Macaranga gigantifolia Merr

Akhmad Darmawan, Soleh Kosela, Leonardus B.S. Kardono, Yana M. Syah

Department of Chemistry

Research output: Contribution to journal › Article › peer-review

54 Citations (Scopus)

Abstract

Scopoletin (1), a coumarin derivative compound has been isolated from methanol extract of Macaranga gigantifolia Merr. leaves using chromatography methods. Chemical structure determination carried out based on spectroscopic data and compared with a reference. Scopoletin cytotoxicity test using MTT assay method against P-388 murine leukemia cells showed strong cytotoxic activity with IC₅₀ 17.42 μg/mL.

Original language	English
Pages (from-to)	175-177
Number of pages	3
Journal	Journal of Applied Pharmaceutical Science
Volume	2
Issue number	12
DOIs	https://doi.org/10.7324/JAPS.2012.21231
Publication status	Published - Dec 2012

Keywords

Coumarin derivative
Macaranga gigantifolia merr
Scopoletin

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abstract = "Scopoletin (1), a coumarin derivative compound has been isolated from methanol extract of Macaranga gigantifolia Merr. leaves using chromatography methods. Chemical structure determination carried out based on spectroscopic data and compared with a reference. Scopoletin cytotoxicity test using MTT assay method against P-388 murine leukemia cells showed strong cytotoxic activity with IC50 17.42 μg/mL.",

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Scopoletin, a coumarin derivative compound isolated from Macaranga gigantifolia Merr

Abstract

Keywords

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