Scopoletin, a coumarin derivative compound isolated from Macaranga gigantifolia Merr

Akhmad Darmawan, Soleh Kosela, Leonardus B.S. Kardono, Yana M. Syah

Research output: Contribution to journalArticlepeer-review

30 Citations (Scopus)

Abstract

Scopoletin (1), a coumarin derivative compound has been isolated from methanol extract of Macaranga gigantifolia Merr. leaves using chromatography methods. Chemical structure determination carried out based on spectroscopic data and compared with a reference. Scopoletin cytotoxicity test using MTT assay method against P-388 murine leukemia cells showed strong cytotoxic activity with IC50 17.42 μg/mL.

Original languageEnglish
Pages (from-to)175-177
Number of pages3
JournalJournal of Applied Pharmaceutical Science
Volume2
Issue number12
DOIs
Publication statusPublished - 1 Dec 2012

Keywords

  • Coumarin derivative
  • Macaranga gigantifolia merr
  • Scopoletin

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