Scale-up production simulation of tooth gel containing casein phophopeptide - Amorphous calcium phosphate (CPP-ACP) and propolis to inhibit teeth demineralization

Dental and oral disease is one of public health problem in Indonesia. The national prevalence of dental and oral problems reach 25.9%. Nowadays, a teeth vitamin in the form of gel is developed with active compound CPP-ACP and propolis to prevent teeth demineralization. This product has been through various research and ready to distribute in the market for people. This research and simulation are aimed for knowing the production units, cost structure, factory feasibility, and factory's cost sensitivity to scale up of teeth vitamin CPP-ACP with the basis of 10-litre milk per batch production. The result of the simulation is the production unit is the main reactor, a filtration unit, a drum drying, and a blending tank. The capital investment cost from this simulation is $288,098 (USD)/year, NPV is $493,402 (USD), IRR is 46.46%, and payback time is 2.15 years. The amount of investment will be sensitive at US$968,926 and annual benefit will be sensitive at $304,840 (USD). The sensitivity analysis for the increasing of raw material shown that the increase of raw material until 70% will make this investment will not feasible economically (MARR 6.5%) with IRR 6.64% and NPV -$5,237 (USD).