Scale-up production simulation of tooth gel containing casein phophopeptide - Amorphous calcium phosphate (CPP-ACP) and propolis to inhibit teeth demineralization

Muhamad Sahlan, Fakhri Rafiki, Risqa Rina Darwita, Anondho Wijanarko, Kenny Lischer, Muhammad Afif

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

Dental and oral disease is one of public health problem in Indonesia. The national prevalence of dental and oral problems reach 25.9%. Nowadays, a teeth vitamin in the form of gel is developed with active compound CPP-ACP and propolis to prevent teeth demineralization. This product has been through various research and ready to distribute in the market for people. This research and simulation are aimed for knowing the production units, cost structure, factory feasibility, and factory's cost sensitivity to scale up of teeth vitamin CPP-ACP with the basis of 10-litre milk per batch production. The result of the simulation is the production unit is the main reactor, a filtration unit, a drum drying, and a blending tank. The capital investment cost from this simulation is $288,098 (USD)/year, NPV is $493,402 (USD), IRR is 46.46%, and payback time is 2.15 years. The amount of investment will be sensitive at US$968,926 and annual benefit will be sensitive at $304,840 (USD). The sensitivity analysis for the increasing of raw material shown that the increase of raw material until 70% will make this investment will not feasible economically (MARR 6.5%) with IRR 6.64% and NPV -$5,237 (USD).

Original languageEnglish
Title of host publicationRecent Progress on
Subtitle of host publicationEnergy, Communities and Cities - Proceedings of International Symposium on Sustainable and Clean Energy, ISSCE 2019: Quality in Research 2019
EditorsYuliusman Yuliusman, Cindy Dianita
PublisherAmerican Institute of Physics Inc.
ISBN (Electronic)9780735419896
DOIs
Publication statusPublished - 4 May 2020
Event16th International Conference on Quality in Research, QiR 2019 - 2019 International Symposium on Sustainable and Clean Energy, ISSCE 2019 - Padang, Indonesia
Duration: 22 Jul 201924 Jul 2019

Publication series

NameAIP Conference Proceedings
Volume2230
ISSN (Print)0094-243X
ISSN (Electronic)1551-7616

Conference

Conference16th International Conference on Quality in Research, QiR 2019 - 2019 International Symposium on Sustainable and Clean Energy, ISSCE 2019
CountryIndonesia
CityPadang
Period22/07/1924/07/19

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