Climate change is one of the problems faced today. One of the impacts arising from climate change is a decrease in immunity. The decreased immune system is caused by climate change can modulate the abnormality in white blood cells. Propolis is one of the resin compounds collected from plants by bees and has various benefits. One effect is that propolis has an immunomodulatory effect on the body. In its use, propolis has a strong taste and smell. One method that can be used to disguise the physical properties of propolis is to convert it into microcapsules by spray drying. Utilization of microcapsules can be done in various ways, one of which is utilization by food fortification. This research and simulation are aimed for knowing the production units, cost structure, factory feasibility, and factory's cost sensitivity to scale up of biscuit fortified with propolis with basis of 10 kilograms of flour perbatch. The result of the simulation is the production unit mixer, oven, extruder, and belt conveyor. The capital investment cost from this simulation is USD297,000,000/year, NPV is USD96,000, IRR is 17.89%, and payback time is 6.04 years. The sensitivity analysis for the fluctuation of product price shown that the decrease of product price by 10% will make this investment will not feasible economically with IRR 5.08% and NPV -$48,000 (USD).