Sarcopenia are Associated with Poor Performance Status in Indonesian Patients with Hepatocellular Carcinoma

C. Rinaldi Lesmana; Edy Rizal Wahyudi; Hamzah Shatri; Aulia Rizka; Irsan Hasan; Thariqah Salamah

doi:10.24871/231202217-23

Sarcopenia are Associated with Poor Performance Status in Indonesian Patients with Hepatocellular Carcinoma

C. Rinaldi Lesmana, Edy Rizal Wahyudi, Hamzah Shatri, Aulia Rizka, Irsan Hasan, Thariqah Salamah

Research output: Contribution to journal › Article › peer-review

Abstract

Background: Sarcopenia affects hepatocellular carcinoma (HCC) prognosis. Sarcopenia can be assessed by using skeletal muscle index (SMI), measured on transverse CT images at the third lumbar vertebra (L3). HCC staging consists of liver function assessment and Eastern Cooperative Oncology Group performance status (ECOG-PS). ECOG-PS can reflect physical function. This study was aimed to describe the proportion of sarcopenia among adults, using Japan Society of Hepatology criteria and explore association between sarcopenia and poor performance status.

Method: The study was conducted in a tertiary hospital during January – October 2021. SMI were evaluated using computed tomography images of L3 in 85 HCC patients. Clinical, laboratory and body composition data were analyzed using bivariate analysis. Logistic regression was performed to obtain an independent association between ECOG-PS and sarcopenic status of HCC patients.

Results: Eighty-five HCC patients (median age, 52 years) were analyzed. Sarcopenia was observed in 49,4% of HCC patients. On multivariate binary regression analysis, a poor ECOG-PS remained independently associated with sarcopenia in HCC (adjusted OR = 4.169 (CI 95% = 1.504-11,555), p < 0,006).

Conclusion: Sarcopenia has high proportion in HCC patients. There were strong association between ECOG-PS and sarcopenia in HC.

Original language	English
Pages (from-to)	17-23
Journal	The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy
Volume	23
Issue number	1
DOIs	https://doi.org/10.24871/231202217-23
Publication status	Published - 1 Apr 2022

Keywords

sarcopenia
hepatocellular carcinoma
L3-SMI
ECOG
Indonesia

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title = "Sarcopenia are Associated with Poor Performance Status in Indonesian Patients with Hepatocellular Carcinoma",

abstract = "Background: Sarcopenia affects hepatocellular carcinoma (HCC) prognosis. Sarcopenia can be assessed by using skeletal muscle index (SMI), measured on transverse CT images at the third lumbar vertebra (L3). HCC staging consists of liver function assessment and Eastern Cooperative Oncology Group performance status (ECOG-PS). ECOG-PS can reflect physical function. This study was aimed to describe the proportion of sarcopenia among adults, using Japan Society of Hepatology criteria and explore association between sarcopenia and poor performance status.Method: The study was conducted in a tertiary hospital during January – October 2021. SMI were evaluated using computed tomography images of L3 in 85 HCC patients. Clinical, laboratory and body composition data were analyzed using bivariate analysis. Logistic regression was performed to obtain an independent association between ECOG-PS and sarcopenic status of HCC patients.Results: Eighty-five HCC patients (median age, 52 years) were analyzed. Sarcopenia was observed in 49,4% of HCC patients. On multivariate binary regression analysis, a poor ECOG-PS remained independently associated with sarcopenia in HCC (adjusted OR = 4.169 (CI 95% = 1.504-11,555), p < 0,006).Conclusion: Sarcopenia has high proportion in HCC patients. There were strong association between ECOG-PS and sarcopenia in HC.",

keywords = "sarcopenia, hepatocellular carcinoma, L3-SMI, ECOG, Indonesia",

author = "Lesmana, {C. Rinaldi} and Wahyudi, {Edy Rizal} and Hamzah Shatri and Aulia Rizka and Irsan Hasan and Thariqah Salamah",

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T1 - Sarcopenia are Associated with Poor Performance Status in Indonesian Patients with Hepatocellular Carcinoma

AU - Lesmana, C. Rinaldi

AU - Wahyudi, Edy Rizal

AU - Shatri, Hamzah

AU - Rizka, Aulia

AU - Hasan, Irsan

AU - Salamah, Thariqah

PY - 2022/4/1

Y1 - 2022/4/1

N2 - Background: Sarcopenia affects hepatocellular carcinoma (HCC) prognosis. Sarcopenia can be assessed by using skeletal muscle index (SMI), measured on transverse CT images at the third lumbar vertebra (L3). HCC staging consists of liver function assessment and Eastern Cooperative Oncology Group performance status (ECOG-PS). ECOG-PS can reflect physical function. This study was aimed to describe the proportion of sarcopenia among adults, using Japan Society of Hepatology criteria and explore association between sarcopenia and poor performance status.Method: The study was conducted in a tertiary hospital during January – October 2021. SMI were evaluated using computed tomography images of L3 in 85 HCC patients. Clinical, laboratory and body composition data were analyzed using bivariate analysis. Logistic regression was performed to obtain an independent association between ECOG-PS and sarcopenic status of HCC patients.Results: Eighty-five HCC patients (median age, 52 years) were analyzed. Sarcopenia was observed in 49,4% of HCC patients. On multivariate binary regression analysis, a poor ECOG-PS remained independently associated with sarcopenia in HCC (adjusted OR = 4.169 (CI 95% = 1.504-11,555), p < 0,006).Conclusion: Sarcopenia has high proportion in HCC patients. There were strong association between ECOG-PS and sarcopenia in HC.

AB - Background: Sarcopenia affects hepatocellular carcinoma (HCC) prognosis. Sarcopenia can be assessed by using skeletal muscle index (SMI), measured on transverse CT images at the third lumbar vertebra (L3). HCC staging consists of liver function assessment and Eastern Cooperative Oncology Group performance status (ECOG-PS). ECOG-PS can reflect physical function. This study was aimed to describe the proportion of sarcopenia among adults, using Japan Society of Hepatology criteria and explore association between sarcopenia and poor performance status.Method: The study was conducted in a tertiary hospital during January – October 2021. SMI were evaluated using computed tomography images of L3 in 85 HCC patients. Clinical, laboratory and body composition data were analyzed using bivariate analysis. Logistic regression was performed to obtain an independent association between ECOG-PS and sarcopenic status of HCC patients.Results: Eighty-five HCC patients (median age, 52 years) were analyzed. Sarcopenia was observed in 49,4% of HCC patients. On multivariate binary regression analysis, a poor ECOG-PS remained independently associated with sarcopenia in HCC (adjusted OR = 4.169 (CI 95% = 1.504-11,555), p < 0,006).Conclusion: Sarcopenia has high proportion in HCC patients. There were strong association between ECOG-PS and sarcopenia in HC.

KW - sarcopenia

KW - hepatocellular carcinoma

KW - L3-SMI

KW - ECOG

KW - Indonesia

UR - https://www.ina-jghe.com/index.php/jghe/article/view/822

U2 - 10.24871/231202217-23

DO - 10.24871/231202217-23

M3 - Article

SN - 2302-8181

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JO - The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy

JF - The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy

IS - 1

ER -

Sarcopenia are Associated with Poor Performance Status in Indonesian Patients with Hepatocellular Carcinoma

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