Salivary bone-specific alkaline phosphatase as predictor of puberty phase

Harryanto Wijaya, Lindawati S. Kusdhany, Sri Redjeki, Benny M. Soegiharto

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)


The identification of the puberty phase is crucial, as it enhances the efficiency and effectiveness of malocclusion treatment. The observation or evaluation of bone morphology developments and changes through radiographs, known as the skeletal maturation method, is the most valid puberty phase indicator. Since this method requires radiographic exposure, a new, non-invasive prediction method for the puberty phase is needed. This study aimed to analyze the potential of the level of salivary bone-specific alkaline phosphatase (BALP), chronological age, and Body Mass Index (BMI) percentile as predictors of the puberty phase. The cross-sectional study included 136 subjects categorized into three phases of puberty based on Bacceti's Cervical Vertebrae Maturation System. Salivary BALP level was determined using a commercial enzyme-linked immunosorbent assay kit. Multinomial logistic regression analysis produced a predictive model with a correct classification rate of 78% in the pre-peak phase, 57.7% in the peak phase, and 81.4% in the post-peak phase. The puberty phase, especially at pre and post-peak, can be predicted with salivary BALP level, chronological age, and BMI percentile.

Original languageEnglish
Pages (from-to)1063-1067
Number of pages5
JournalJournal of International Dental and Medical Research
Issue number3
Publication statusPublished - 1 Jan 2019


  • Body Mass Index
  • Cervical Vertebrae Maturation System
  • Chronological age
  • Puberty
  • Salivary bone-specific alkaline phosphatase


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