@inproceedings{0c3dcf1363804cc1a14a20e5e44bfdd7,
title = "Safety Evaluation of Garcinia mangostana Linn Microparticle Extract on BALB/c Mice Renal Function",
abstract = "This experimental study was conducted to assess the general safety of Garcinia mangostana Linn microparticle extract on BALB/c mice renal function after 14 days of administration. In this experimental study, the microparticles of G. mangostana extract were wrapped in chitosan alginate capsules to reach the target organ effectively. BALB/c mice were divided into the control group and treatment group (2 g/kg BW, 1 g/kg BW, and 0.5 g/kg BW). Renal physiology was assessed from Blood Urea Nitrogen (BUN) level and creatinine level after 14 days of treatment. BUN and creatinine levels were found significant in male mice (p = 0.021 and p = 0.043) at doses of 2 g/kg BW when compared to control. G. mangostana extract did not affect renal weight. Signs of clinical toxicity were not seen during the treatment. These results designate that microencapsulation of G. mangostana Linn increases BUN and creatinine if given at 2 g/kg BW dose for 14 days on male mice. The extract G. mangostana Linn is secure until 2 g/kg BW of dose for 14 days of administration on BALB/c mice.",
keywords = "BUN, creatinine, Garcinia mangostana Linn extract, Safety evaluation",
author = "Andayani, {Ni Gusti Agung Ayu Putu Tika} and Krisnamurti, {Desak Gede Budi} and Siti Farida",
note = "Funding Information: This study was supported by the Faculty of Medicine, Universitas Indonesia. This study is used as a thesis to get a bachelor's degree in medicine. Publisher Copyright: {\textcopyright} 2022 American Institute of Physics Inc.. All rights reserved.; 6th International Symposium of Biomedical Engineering''s Recent Progress in Biomaterials, Drugs Development, and Medical Devices, ISBE 2021 ; Conference date: 07-07-2021 Through 08-07-2021",
year = "2022",
month = aug,
day = "16",
doi = "10.1063/5.0098199",
language = "English",
series = "AIP Conference Proceedings",
publisher = "American Institute of Physics Inc.",
editor = "Rahman, {Siti Fauziyah} and Ahmad Zakiyuddin and Yudan Whulanza and Nurul Intan",
booktitle = "6th Biomedical Engineering''s Recent Progress in Biomaterials, Drugs Development, and Medical Devices",
address = "United States",
}