Safety and effectiveness of switching from a basal-only to biphasic insulin aspart 30 insulin regimen

Jihad Haddad, Mohsen Khoshniatnikoo, Youcef Benabbas, Serdar Guler, Vinay Prusty, Pradana Soewondo

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

Purpose: This sub-analysis of the A1chieve study evaluated the safety and effectiveness of changing from a basal-only insulin regimen to biphasic insulin aspart 30. Methods: A1chieve was an international, multicenter, prospective, open-label, non- interventional, 24-week study in people with type 2 diabetes mellitus starting/switching to therapy with biphasic insulin aspart 30, insulin detemir, or insulin aspart (alone/in combination) in routine clinical practice. This sub-analysis evaluated the safety and effectiveness of switching from basal insulin with either insulin glargine (GLA group) or insulin neutral protamine Hagedorn (NEU group) to biphasic insulin aspart 30. Results: A total of 2,818 participants received biphasic insulin aspart 30 (1,395 in the GLA group and 1,423 in the NEU group). After 24 weeks of treatment, there were significant reductions in the proportion of patients with at least one hypoglycemia event: total [baseline vs. 24 weeks: 15.5% vs. 9.7% (p<0.001) and 12.3% vs. 9.9% (p<0.05), in NEU and GLA groups, respectively], major [2.5% vs. 0.08% (p<0.001) and 1.2% vs. 0.08% (p<0.001), in NEU and GLA groups, respectively] and nocturnal hypoglycemia [7.2% vs. 3.5% (p<0.001) and 5.4% vs. 3.9% (p<0.05), in NEU and GLA groups, respectively]. After 24 weeks of biphasic insulin aspart 30 there were statistically significant improvements from baseline in glycated hemoglobin, fasting plasma glucose, and post-prandial plasma glucose levels (p<0.001) and in health-related quality of life (p<0.001) in both groups. Conclusions: Biphasic insulin aspart 30 may benefit patients with poor glycemic control on basal insulin regimens who are seeking to change treatment.

Original languageEnglish
Pages (from-to)309-319
Number of pages11
JournalDiabetes Therapy
Volume4
Issue number2
DOIs
Publication statusPublished - 1 Jan 2013

Keywords

  • Basal insulin
  • Biphasic insulin aspart 30
  • Effectiveness
  • Type 2 diabetes mellitus

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