Rotavirus detection and the characteristics of NSP4 as enterotoxin to induce invagination in children

Iqbal Pahlevi Nasution, Yati Soenarto, Farid Nurmantu, Adang Bachtiar

Research output: Contribution to journalArticlepeer-review


Invagination is a disease occurs in children that requires emergency action. Factors associated with the occurrence of invagination can’t be exactly determined because 95% of the cause of invagination is unknown (idiopathic), 5% for causal and rotavirus is estimated as one of the risk factors for the occurrence of invagination. Methods: After obtaining approval from the Ethics Committee of the Faculty of Medicine, USU, the parents of the patients were given a detailed explanation of the purpose / benefits of the research, and asked for the consent. Stool examination is divided into two groups which are invagination and diarrhea group. Stool samples are then examined in the laboratory by PCR to determine the presence rotavirus. Results: 83.3% overnourished children have invagination. Chi square analysis showed that there is no correlation between sex and ethnic group and invagination (p>0,05). 72.7% of Batak ethnic group has invagination and the rest 57.6% of the patient is not. There are 82.1% patients found positive with rotavirus type A whereas patients with diarrhea found as many as 17.9 %. There is a significant correlation between the incidence of rotavirus infection and invagination (p= 0.004). There was no significant relationship between NSP4 and invagination (p = 1.000). Conclusion: There is a significant relationship between nutrition status with incidence of invagination (p=0.034). The OR value is 1.542 (95% CI 1.074 – 2.214). This means that the children with overnutrition were at risk to have invagination 1.542 times more than the children with malnutrition. As many as 83.3% children with overnutrition suffer from invagination. No significant relationship between NSP4 and the incidence of invagination (p = 1.000). A total of 62.5% of children are found to have NSP4 invagination, whereas the group of children suffering from invagination with no founded NSP4 is about 63.8%.

Original languageEnglish
Pages (from-to)250-255
Number of pages6
JournalInternational Journal of PharmTech Research
Issue number2
Publication statusPublished - 2015


  • Ethnic
  • Invagination
  • NSP4
  • Nutrient
  • Rotavirus


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