Role of ursodeoxycholic acid in neonatal indirect hyperbilirubinemia: a systematic review and meta-analysis of randomized controlled trials

Glen Lazarus, Jerrell Francie, Rosalina Dewi Roeslani, Siti Rizny Fitriana Saldi, Hanifah Oswari

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Neonatal jaundice is a transitional phenomenon affecting three out of five full-term newborns globally. Ursodeoxycholic acid could be beneficial in neonatal jaundice needing phototherapy. Methods: We searched PubMed, EBSCO, ProQuest, and Cochrane Library up to August 21st, 2021, for articles to be reviewed. Meta-analysis using random-effects model was performed. Results: Eight studies involving 1116 neonates were chosen in this review; however, only five studies were included for meta-analysis. Phototherapy duration was significantly lower in the interventional group with high heterogeneities. Subgroup analysis of the phototherapy duration based on the risk of bias resulted in a shorter duration (mean difference (MD) = –17.82; 95% CI = –20.17 to –15.47; p = < 0.001) with low heterogeneity in the treatment group. Secondary outcome focusing on mean total serum bilirubin showed a lower mean total serum bilirubin in 48 h post-treatment (MD = –0.43; 95% CI = –0.64 to –0.22; p = < 0.0001) with low heterogeneities in Asian countries.” Conclusions: Ursodeoxycholic acid might be considered as a novel adjuvant therapy in neonatal indirect hyperbilirubinemia to shorten the phototherapy duration and lower the mean total serum bilirubin.

Original languageEnglish
Article number179
JournalItalian Journal of Pediatrics
Volume48
Issue number1
DOIs
Publication statusPublished - Dec 2022

Keywords

  • Neonatal hyperbilirubinemia
  • Neonatal jaundice
  • Phototherapy
  • URSODEOXYCHOLIC ACID
  • Ursodiol

Fingerprint

Dive into the research topics of 'Role of ursodeoxycholic acid in neonatal indirect hyperbilirubinemia: a systematic review and meta-analysis of randomized controlled trials'. Together they form a unique fingerprint.

Cite this