Role of differential signaling pathways and oxidative stress in diabetic cardiomyopathy

Kenichi Watanabe, Rajarajan A. Thandavarayan, Meilei Harima, Flori R. Sari, Narasimman Gurusamy, Punniyakoti T. Veeraveedu, Sayaka Mito, Wawaimuli Arozal, Vijayakumar Sukumaran, Arun Prasath Laksmanan, Vivian, Makoto Kodama, Yoshifusa Aizawa

Research output: Contribution to journalArticlepeer-review

67 Citations (Scopus)

Abstract

Diabetes mellitus increases the risk of heart failure independently of underlying coronary artery disease, and many believe that diabetes leads to cardiomyopathy. The underlying pathogenesis is partially understood. Several factors may contribute to the development of cardiac dysfunction in the absence of coronary artery disease in diabetes mellitus. There is growing evidence that excess generation of highly reactive free radicals, largely due to hyperglycemia, causes oxidative stress, which further exacerbates the development and progression of diabetes and its complications. Hyperglycemia- induced oxidative stress is a major risk factor for the development of micro-vascular pathogenesis in the diabetic myocardium, which results in myocardial cell death, hypertrophy, fibrosis, abnormalities of calcium homeostasis and endothelial dysfunction. Diabetes-mediated biochemical changes show cross-interaction and complex interplay culminating in the activation of several intracellular signaling molecules. Diabetic cardiomyopathy is characterized by morphologic and structural changes in the myocardium and coronary vasculature mediated by the activation of various signaling pathways. This review focuses on the oxidative stress and signaling pathways in the pathogenesis of the cardiovascular complications of diabetes, which underlie the development and progression of diabetic cardiomyopathy.

Original languageEnglish
Pages (from-to)280-290
Number of pages11
JournalCurrent Cardiology Reviews
Volume6
Issue number4
DOIs
Publication statusPublished - 1 Dec 2010

Keywords

  • Apoptosis
  • Cardiomyopathy
  • Diabetes mellitus
  • Hypertrophy
  • Oxidative stress

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