TY - JOUR
T1 - Risk factors for the development and progression of retinopathy of prematurity in preterm infants in Indonesia
AU - Siswanto, J. E.
AU - Ronoatmodjo, S.
AU - Adisasmita, A.
AU - Soemantri, A.
AU - Sitorus, R. S.
AU - Sauer, P. J.J.
N1 - Funding Information:
This work was carried out and supported by the Harapan Kita Children’s and Women’s Hospital, the Eye Centers Kebon Jeruk and Menteng, and Budi Kemuliaan Hospital, all situated in Jakarta. Indonesia. We would like to thank all doctors, especially Nani H. Widodo MD and Florence Manurung MD, who conducted the ophthalmologic examination in the preterm infants whom we studied in this research. We thank Dr. T. van Wulfften Palthe for correcting the English language.
Publisher Copyright:
© 2020 - IOS Press and the authors. All rights reserved.
PY - 2020/1/1
Y1 - 2020/1/1
N2 - BACKGROUND: Risk factors other than supplemental oxygen might play a role in the development of retinopathy of prematurity (ROP). In Indonesia ROP occurs in infants up to 34 weeks and 2000g. Risk factors for the development of ROP in Indonesian NICUs have not been evaluated. Our aim was to identify other risk factors than the use of oxygen in the development and progression of ROP in preterm infants in Indonesia. METHODOLOGY: Data on 98 preterm infants with ROP and 77 controls were collected from four NICUs and two eye centers in Jakarta, Indonesia, between 2009 and 2014. We used multivariate logistic regression analysis to determine the relationship between infants and environmental variables and the development and progression of ROP. We obtained variables for ROP severity by using Cox regression analysis. RESULTS: Factors associated with the development of ROP were birthweight (BWt), intrauterine growth retardation (IUGR), exchange transfusion, duration of oxygen supplementation, minimum saturation monitor setting, and socioeconomic factors. Regarding the progression, gestational age (GA), out-born, duration of supplemental oxygen, minimum saturation monitor setting, and socioeconomic factors were identified as risk factors. CONCLUSION: The use and control of supplemental oxygen are the main risk factors for the development and progression of ROP in preterms in Indonesia. Additionally, we confirm that GA, BWt, and IUGR are risk factors. Moreover, we found exchange transfusion to be a risk factor, and we found a lower rate of ROP in infants from a lower socioeconomic background. These risk factors apply to infants with a GA up to 34 weeks and a BWt up to 2000g.
AB - BACKGROUND: Risk factors other than supplemental oxygen might play a role in the development of retinopathy of prematurity (ROP). In Indonesia ROP occurs in infants up to 34 weeks and 2000g. Risk factors for the development of ROP in Indonesian NICUs have not been evaluated. Our aim was to identify other risk factors than the use of oxygen in the development and progression of ROP in preterm infants in Indonesia. METHODOLOGY: Data on 98 preterm infants with ROP and 77 controls were collected from four NICUs and two eye centers in Jakarta, Indonesia, between 2009 and 2014. We used multivariate logistic regression analysis to determine the relationship between infants and environmental variables and the development and progression of ROP. We obtained variables for ROP severity by using Cox regression analysis. RESULTS: Factors associated with the development of ROP were birthweight (BWt), intrauterine growth retardation (IUGR), exchange transfusion, duration of oxygen supplementation, minimum saturation monitor setting, and socioeconomic factors. Regarding the progression, gestational age (GA), out-born, duration of supplemental oxygen, minimum saturation monitor setting, and socioeconomic factors were identified as risk factors. CONCLUSION: The use and control of supplemental oxygen are the main risk factors for the development and progression of ROP in preterms in Indonesia. Additionally, we confirm that GA, BWt, and IUGR are risk factors. Moreover, we found exchange transfusion to be a risk factor, and we found a lower rate of ROP in infants from a lower socioeconomic background. These risk factors apply to infants with a GA up to 34 weeks and a BWt up to 2000g.
KW - neonatal risk factors
KW - oxygen supplementation
KW - retinopathy of prematurity ROP
UR - http://www.scopus.com/inward/record.url?scp=85077617017&partnerID=8YFLogxK
U2 - 10.3233/NPM-190233
DO - 10.3233/NPM-190233
M3 - Article
C2 - 31609708
AN - SCOPUS:85077617017
SN - 1934-5798
VL - 13
SP - 253
EP - 260
JO - Journal of Neonatal-Perinatal Medicine
JF - Journal of Neonatal-Perinatal Medicine
IS - 2
ER -