Risk factors and laboratory test results associated with severe illness and mortality in COVID-19 patients: A systematic review

Siti Setiati, Kuntjoro Harimurti, Eka Dian Safitri, Respati W. Ranakusuma, Siti Rizny F. Saldi, Muhammad K. Azwar, Jessica Marsigit, Yupitri Pitoyo, Widyaningsih Widyaningsih

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

BackgroundWe aimed to systematically review all relevant studies related to the risk factors and laboratory test results associated with severe illness and mortality in COVID-19 patients.MethodsWe utilised PubMed, Scopus, ProQuest, Wiley Online Library, ScienceDirect and MedRxiv to search for studies, with additional hand-searched journals. We included systematic reviews/meta-analyses, cohort and case control studies of suspected and/or confirmed COVID-19 cases with severe illness and/or mortality as outcomes. We included laboratory test results and risk factors. We assessed risk of bias using ROBIS-I and Newcastle-Ottawa Scale assessment tool. Type of study, risk of bias, and precision of results determined evidence sufficiency.ResultsOf 26 records included, sufficient evidence suggested the association between age >60 years, hypertension, coronary heart disease, DM, serum LDH 250-500 U/L, LDH >500 U/L, and lymphopenia (lymphocyte count ≤1.0 x 109 /L) and severe illness of COVID-19. CD3+CD8+ cell count ≤ 75 cell/μl, D-dimer > 1 mg/L, AKI stage 2 and 3, proteinuria ≥1+, hematuria ≥1+, and peak serum creatinine > 13.26 μmol/L are associated with mortality.ConclusionAge >60 years, hypertension, DM, and coronary heart disease are the risk factors for severe illness of COVID-19. Laboratory test results associated with severe illness are serum LDH 250-500 U/L, LDH >500 U/L, and lymphopenia, whereas test results associated with mortality are CD3+CD8+ cell count ≤ 75 cell/μl, AKI stage 2 and 3, proteinuria ≥1+, hematuria ≥1+, D-dimer > 1 mg/L, peak serum creatinine > 13.26 μmol/L.

Original languageEnglish
Pages (from-to)227-245
Number of pages19
JournalActa medica Indonesiana
Volume52
Issue number3
Publication statusPublished - 1 Jul 2020

Keywords

  • COVID-19
  • laboratory test
  • mortality
  • risk factor
  • severe illness

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