Release Profile of Andrographis paniculata Leaf Extract Nanocapsule as α-Glucosidase Inhibitors

K. Zahrani, F. Imansari, Tania Surya Utami, Rita Arbianti

Research output: Contribution to journalConference articlepeer-review

Abstract

Andrographis paniculata is one of 13 leading commodities Indonesian medicinal plants through the Ditjen POM. Andrographolide as main active compound has been shown to have many pharmacological activities, one of which is as α-glucosidase enzyme inhibitors which has clinical potential as an antitumor, antiviral, antidiabetic, and immunoregulator agents. This study aims to do nanoencapsulation of Andrographis paniculatar leaf extract to increase its active compound bioavailability and get a release profile through synthetic fluids media simulation. Nanoencapsulation with ionic gelation method result the encapsulation efficiency and loading capacity values of 73.47% and 46.29% at 2%: 1% of chitosan: STPP ratio. The maximum α-glucosidase inhibition of 37.17% was obtained at 16% concentration. Burst release at gastric pH conditions indicate that most of the drug (in this study is an Andrographis paniculata leaf extract) adsorbed on the surface of the nanoparticles an indicates that the kind of nanoparticle formed is nanosphere.

Original languageEnglish
Article number012020
JournalIOP Conference Series: Materials Science and Engineering
Volume214
Issue number1
DOIs
Publication statusPublished - 6 Jul 2017
Event2nd Materials Research Society of Indonesia Meeting, MRS-Id 2016 - Bandung, West Java, Indonesia
Duration: 24 Oct 201626 Oct 2016

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