Release Profile and Inhibition Test of the Nanoparticles A. Paniculata Extract as Inhibitor of α-Glucosidase in the Process of Carbohydrates Breakdown into Glucose Diabetes Mellitus

Farisa Imansari, Muhamad Sahlan, Rita Arbianti

Research output: Contribution to journalConference articlepeer-review

1 Citation (Scopus)

Abstract

Andrographis paniculata (A.paniculata) contain the main active substances Andrographolide which helps lower glucose levels in diabetics by inhibiting the enzyme α-glucosidase. The ability of the extract A.paniculata in lowering glucose levels will increase with the technique encapsulation with a coating of composition Chitosan-STPP as a drug delivery to the target organ. This study aimed to get an overview of A.paniculata release profile of nanoparticles in a synthetic fluid media with various concentrations of coating and inhibition testing nasty shard extract in inhibiting the enzyme α-glucosidase. This research resulted in nanoparticles by coating efficiency and loading capacity of chitosan greatest variation of 2% and 1% STPP 60% and 46.29%. chitosan greatest variation of 2% and 1% STPP 60% and 46.29%. The ability of A.paniculata extracts as α-glucosidase enzyme inhibitors has been demonstrated in this study, the percent inhibition of 33.17%.

Original languageEnglish
Article number012026
JournalIOP Conference Series: Materials Science and Engineering
Volume214
Issue number1
DOIs
Publication statusPublished - 6 Jul 2017
Event2nd Materials Research Society of Indonesia Meeting, MRS-Id 2016 - Bandung, West Java, Indonesia
Duration: 24 Oct 201626 Oct 2016

Fingerprint Dive into the research topics of 'Release Profile and Inhibition Test of the Nanoparticles A. Paniculata Extract as Inhibitor of α-Glucosidase in the Process of Carbohydrates Breakdown into Glucose Diabetes Mellitus'. Together they form a unique fingerprint.

Cite this