TY - JOUR
T1 - Relationship between lipid profiles with carotid intima--media thickness in children with type I diabetes mellitus
AU - Sukardi, Rubiana
AU - Madiyono, Bambang
AU - Sastroasmoro, Sudigdo
AU - Batubara, Jose Rl
PY - 2008
Y1 - 2008
N2 - Background The major cause of morbidity and mortality in
patients with type I diabetes mellitus is premature and extensive
artherosclerosis. Carotid intima-media thickness (IMT) is
associated with cardivascular risk factors and has been used as a
marker of early artherosclerosis process.
Objective To determine IMT of carotid artery and its relationship
with duration of diabetes, lipid profiles, and mean HbA 1 level.
Methods A cross-sectional study was conducted on patients
with type 1 DM at the Department of Child Health Cipto
Mangunkusumo Hospital. Ultrasound B-mode imaging was
performed to measure the IMT. Age-matched non-diabtetic
subjects served as controls. Statistical significant was assumed
at P<O.S.
Results The mean IMT values of type I DM patients aged < 12
years, 12-18 years, 18+ years were 0.44 (SD 0.03) mm; 0.46
(SD 0.01) mm; 0.51 (SD 0.01) mm, respectively, which were
significantly greater than those of age-matched non-diabetic
subjects which were 0.39 (SD 0.01), 0.41 (SD 0.01) mm, 0.46
(SD 0.01) mm, respectively. Patients with type I DM had a
higher apolipoprotein-Band HDL cholesterol levels than in non-
diabetic subjects. Multiple regression analysis showed that there
was no relationship between total cholesterol, cholesterol LDL,
chronic hyperglycemia (HbA 1) and IMT. However, IMT in type
I diabetes was linearly related with duration of diabetes .
Conclusion Type I DM patients have greater IMT and higher
mean apolipoprotein B. There is a strong correlation between
IMT and duration of diabetes.
AB - Background The major cause of morbidity and mortality in
patients with type I diabetes mellitus is premature and extensive
artherosclerosis. Carotid intima-media thickness (IMT) is
associated with cardivascular risk factors and has been used as a
marker of early artherosclerosis process.
Objective To determine IMT of carotid artery and its relationship
with duration of diabetes, lipid profiles, and mean HbA 1 level.
Methods A cross-sectional study was conducted on patients
with type 1 DM at the Department of Child Health Cipto
Mangunkusumo Hospital. Ultrasound B-mode imaging was
performed to measure the IMT. Age-matched non-diabtetic
subjects served as controls. Statistical significant was assumed
at P<O.S.
Results The mean IMT values of type I DM patients aged < 12
years, 12-18 years, 18+ years were 0.44 (SD 0.03) mm; 0.46
(SD 0.01) mm; 0.51 (SD 0.01) mm, respectively, which were
significantly greater than those of age-matched non-diabetic
subjects which were 0.39 (SD 0.01), 0.41 (SD 0.01) mm, 0.46
(SD 0.01) mm, respectively. Patients with type I DM had a
higher apolipoprotein-Band HDL cholesterol levels than in non-
diabetic subjects. Multiple regression analysis showed that there
was no relationship between total cholesterol, cholesterol LDL,
chronic hyperglycemia (HbA 1) and IMT. However, IMT in type
I diabetes was linearly related with duration of diabetes .
Conclusion Type I DM patients have greater IMT and higher
mean apolipoprotein B. There is a strong correlation between
IMT and duration of diabetes.
UR - https://paediatricaindonesiana.org/index.php/paediatrica-indonesiana/article/view/522
U2 - 10.14238/pi48.3.2008
DO - 10.14238/pi48.3.2008
M3 - Article
SN - 0030-9311
VL - 48
SP - 147
EP - 151
JO - Paediatrica Indonesiana
JF - Paediatrica Indonesiana
IS - 3
ER -