@article{0a8f50b3a01547b691fbdc5dd8a5b4e7,
title = "Regio-complementary preparation of 6- And 7-fluoro-1,2,3,4-tetrahydroquinolines via the cyclization of catecholamines followed by deoxyfluorination",
abstract = "We herein report a regioselective preparation of 6- and 7-fluoro-1,2,3,4-tetrahydroquinolines by applying the deoxyfluorination strategy, developed by the authors. This method includes the cyclization of catecholamines bearing an N-protecting group to form 7-hydroxy-1-azaspiro[4.5]deca-6,9-dien-8-ones and 6,7-dihydroxy-1,2,3,4-tetrahydroquinolines followed by deoxyfluorination, in which the nature of the N-protecting group has a significant effect on both the cyclization and the regioselectivity of the deoxyfluorination reaction.",
author = "Kazuyuki Saito and Wang Zhou and Shohei Sato and Keita Takubo and Kazunori Furutsu and Mohamed, \{Ahmed A.B.\} and Purwati, \{Euis Maras\} and Takashi Ikawa and Shuji Akai",
note = "Funding Information: This work was financially supported by the JSPS KAKENHI [18HO4411 (Middle Molecular Strategy)] and Platform Project for Supporting Drug Discovery and Life Science Research (Basis for Supporting Innovative Drug Discovery and Life Science Research (BINDS)) from AMED under Grant Number JP20am0101084. Publisher Copyright: {\textcopyright} 2021 Japan Institute of Heterocyclic Chemistry. All rights reserved.",
year = "2021",
doi = "10.3987/COM-20-S(K)56",
language = "English",
volume = "103",
journal = "Heterocycles",
issn = "0385-5414",
publisher = "Japan Institute of Heterocyclic Chemistry",
number = "2",
}