Reduction of blood IL-6 level on aged Sprague-Dawley rats treated with Acalypha indica Linn ethanolic extract

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Aging is a condition of impaired function due to the decrease of physiological integrity that can be a risk factor for another significant disease. The aging process is caused by free radicals that can damage the surrounding molecules. This process can cause oxidative stress and increase the level of proinflammatory mediators, such as interleukin-6 (IL-6). Acalypha indica Linn (AI), is widely used as an herbal medicine for various diseases. Several studies have shown that Acalypha indica Linn have antioxidant and anti-inflammatory effects. We aimed to study the impact of AI on aged Sprague-Dawley (SD) rats. The rats were divided into 4 groups consists of 7 rats on each group. The groups are treated with placebo, the ethanol extract of AI (250mg/kg BW) and vitamin E (6 IU). The last group consists of young SD rats. After 28 days, rats were terminated, and laboratory tests were performed to see blood-IL-6 levels using enzyme-linked immunosorbent assay. The results showed AI significantly reduced blood IL-6 level compared to negative control group (P = 0,0048) while there is no significant difference of blood IL-6 level between treatment group (AI) compared to positive control group. These results prove that AI ethanol extract has an antioxidant effects on aged SD rats and can be a potential antioxidant agent to inhibit aging process.

Original languageEnglish
Title of host publication3rd Biomedical Engineering''s Recent Progress in Biomaterials, Drugs Development, and Medical Devices
Subtitle of host publicationProceedings of the International Symposium of Biomedical Engineering, ISBE 2018
EditorsPraswasti P.D.K. Wulan, Misri Gozan, Sotya Astutiningsih, Ghiska Ramahdita, Radon Dhelika, Prasetyanugraheni Kreshanti
PublisherAmerican Institute of Physics Inc.
ISBN (Electronic)9780735418226
DOIs
Publication statusPublished - 9 Apr 2019
Event3rd International Symposium of Biomedical Engineering''s Recent Progress in Biomaterials, Drugs Development, and Medical Devices, ISBE 2018 - Jakarta, Indonesia
Duration: 6 Aug 20188 Aug 2018

Publication series

NameAIP Conference Proceedings
Volume2092
ISSN (Print)0094-243X
ISSN (Electronic)1551-7616

Conference

Conference3rd International Symposium of Biomedical Engineering''s Recent Progress in Biomaterials, Drugs Development, and Medical Devices, ISBE 2018
CountryIndonesia
CityJakarta
Period6/08/188/08/18

Keywords

  • Acalypha indica Linn
  • Aged Sprague-Dawley rats
  • aging
  • free radicals
  • interleukin-6
  • oxidative stress

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    Nathanael, M., Hakim, R. W., Farida, S., Purwaningsih, E. H., & Krisnamurti, D. G. B. (2019). Reduction of blood IL-6 level on aged Sprague-Dawley rats treated with Acalypha indica Linn ethanolic extract. In P. P. D. K. Wulan, M. Gozan, S. Astutiningsih, G. Ramahdita, R. Dhelika, & P. Kreshanti (Eds.), 3rd Biomedical Engineering''s Recent Progress in Biomaterials, Drugs Development, and Medical Devices: Proceedings of the International Symposium of Biomedical Engineering, ISBE 2018 [030014] (AIP Conference Proceedings; Vol. 2092). American Institute of Physics Inc.. https://doi.org/10.1063/1.5096718