TY - JOUR
T1 - Reconstructing an ovary cancer microenvironment for in vitro 3D drug testing
T2 - A new avenue for ovary cancer research
AU - Antarianto, Radiana Dhewayani
AU - Khaerunnisa, Sanya
AU - Pangjaya, Lady Feren
AU - Hardy Lubis, Dinda Shezaria
AU - Lestari, Retno
N1 - Publisher Copyright:
© 2021 Pakistan Medical Association. All rights reserved.
PY - 2021/2/1
Y1 - 2021/2/1
N2 - OBJECTIVE: To elaborate on in vitro 3D ovary cancer models that can mimic the in vivo condition of an ovary cancer microenvironment for anticancer drug discovery. Methods: Literature research was conducted in NCBI, ScienceDirect, and Pubchem databases. A total of 19 articles relevant to the search terms were included in this review. RESULTS: The ovary cancer niche has been described as the home of cancer stem cells, multipotent stromal cells, fibroblasts, blood and lymphatic vessels, growth factors, extracellular matrix protein (ECM). Cell cancer behaviour toward anticancer drugs can also be altered by deposition of ECM. A human ovary decellularized protocol generates ovary scaffold. Incorporation of cancer stem cells (CSC) in the ovary cancer niche thus yield 3D reconstructed microenvironment for further anticancer drug testing. CONCLUSIONS: The 3D reconstructed microenvironment provides a platform for further anticancer drug testing.
AB - OBJECTIVE: To elaborate on in vitro 3D ovary cancer models that can mimic the in vivo condition of an ovary cancer microenvironment for anticancer drug discovery. Methods: Literature research was conducted in NCBI, ScienceDirect, and Pubchem databases. A total of 19 articles relevant to the search terms were included in this review. RESULTS: The ovary cancer niche has been described as the home of cancer stem cells, multipotent stromal cells, fibroblasts, blood and lymphatic vessels, growth factors, extracellular matrix protein (ECM). Cell cancer behaviour toward anticancer drugs can also be altered by deposition of ECM. A human ovary decellularized protocol generates ovary scaffold. Incorporation of cancer stem cells (CSC) in the ovary cancer niche thus yield 3D reconstructed microenvironment for further anticancer drug testing. CONCLUSIONS: The 3D reconstructed microenvironment provides a platform for further anticancer drug testing.
KW - Cancer microenvironment, Scaffold, Ovary cancer, CSC, ECM.
UR - http://www.scopus.com/inward/record.url?scp=85103744260&partnerID=8YFLogxK
M3 - Article
C2 - 33785957
AN - SCOPUS:85103744260
SN - 0030-9982
VL - 71 2)
SP - S129-S133
JO - JPMA. The Journal of the Pakistan Medical Association
JF - JPMA. The Journal of the Pakistan Medical Association
IS - 2
ER -
