Recognizing true H5N1 infections in humans during confirmed outbreaks

Mukhtiar Zaman, Viktor Gasimov, Ahmet Faik Oner, Nazim Dogan, Wiku Adisasmito, Richard Coker, Ebun L. Bamgboye, Paul K.S. Chan, Wanna Hanshaoworakul, Nelson Lee, Bounlay Phommasack, Sok Touch, Owen Tsang, Anna Swenson, Stephen Toovey, Nancy Ann Dreyer

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)


Introduction: The goal of this study was to evaluate whether any characteristics that are evident at presentation for urgent medical attention could be used to differentiate cases of H5N1 in the absence of viral testing. Methodology: Information about exposure to poultry, clinical signs and symptoms, treatments, and outcomes was abstracted from existing data in the global avian influenza registry ( using standardized data collection tools for documented and possible cases of H5N1 infection who presented for medical attention between 2005-2011 during known H5N1 outbreaks in Azerbaijan, Indonesia, Pakistan and Turkey. Results: Demography, exposure to poultry, and presenting symptoms were compared, with only the common symptoms of fever and headache presenting significantly more frequently in confirmed H5N1 cases than in possible cases. Reported exposure to infected humans was also more common in confirmed cases. In contrast, unexplained respiratory illness, sore throat, excess sputum production, and rhinorrhea were more frequent in possible cases. Overall, oseltamivir treatment showed a survival benefit, with the greatest benefit shown in H5N1 cases who were treated within two days of symptom onset (51% reduction in case fatality). Conclusion: Since prompt treatment with antivirals conferred a strong survival benefit for H5N1 cases, presumptive antiviral treatment should be considered for all possible cases presenting during an outbreak of H5N1 as a potentially life-saving measure.

Original languageEnglish
Pages (from-to)202-207
Number of pages6
JournalJournal of Infection in Developing Countries
Issue number2
Publication statusPublished - Feb 2014


  • Antiviral agents
  • Avian influenza
  • Human
  • Influenza
  • Oseltamivir


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