Realization and testing of lab-on-chip for human lung replication

Yudan Whulanza, Dwisetya Safirna Widyaratih, Jos Istiyanto, Gandjar Kiswanto

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)

Abstract

This research realised 3D constructs so called lab-on-chip as pathways to study human cell under a controlled environment. The chip is a sandwich of two microchannels with microporous membrane in between to mimic human lung system. The challenge is the fabrication of each micro part and assembles them becoming a functional micro system. Firstly, the session was preceded by realization of 20mm x 0.5mm x 0.3mm (length x width x thickness) channels. Later on, porous membrane with size of 100μm x 100μm arranged as arrays were also realised using micro milling apparatus. Eventually, the system was tested by employing 300ml/h propanol and water in each channel. The diffusion of propanol into water channel was validated by gas chromatography (GC) apparatus to validate the functionality of the system.

Original languageEnglish
Pages (from-to)2064-2067
Number of pages4
JournalARPN Journal of Engineering and Applied Sciences
Volume9
Issue number11
Publication statusPublished - 1 Jan 2014

Keywords

  • Lab-on-chip
  • Lung system
  • Micro-assembling
  • Micro-parts

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