Rapid hemostasis of arterial puncture sites with Angio-Seal in patients undergoing percutaneous coronary intervention.

AIM: To evaluate the efficacy and safety of Angio-Seal device in achieving rapid hemostasis of the access site after percutaneous coronary intervention (PCI) compared with manual compression. METHODS: From December 2002 to November 2003, the device was used in 88 nonconsecutive patients underwent PCI, their age was 58 +/- 9 years and 78% were male, and time to hemostasis, time to ambulation and in hospital groin complications were compared to 88 nonconsecutive patients (age 58 +/- 11 years and 77% were male), who had manual compression. RESULTS: Time to hemostasis is significantly shorter in Angio-Seal group compared with manual compression (1.5 +/- 2.0 minutes vs 38.1 +/- 5.4 minutes, p < 0.0001) despite activated clotting time (319 +/- 37 seconds vs 131 +/- 18 seconds, p < 0.0001). Leg immobilization was 4-6 hours in 98% of patients using the Angio-Seal device. While in patients with manual compression the leg immobilization required 10-14 hours. Time to ambulation was significantly shorter in Angio-Seal group compared with manual compression (5.2 +/- 0.6 hours vs 13.0 +/- 0.7 hours. P < 0.05). There was no difference in overall major complication rate found between the two groups. CONCLUSION: This study showed that the Angio-Seal device rapid hemostasis could be obtained in the arterial puncture sites, so that time to ambulation became much shorter with Angio-Seal compared with manual compression, without any significant differences in groin complications.