Questionnaire-Based Survey on Gastrointestinal Bleeding and Management of Antithrombotic Agents during Endoscopy among Asian Countries

Nanae Tsuruoka, Ryuichi Iwakiri, Yasuhisa Sakata, Kazuma Fujimoto, Takeshi Kamiya, Takashi Joh, Kengo Tokunaga, Shin'Ichi Takahashi, Yoshikazu Kinoshita, Kazuhiko Uchiyama, Yuji Naito, Akihito Nagahara, Toshio Watanabe, Francis K.L. Chan, Ki Baik Hahm, Udom Kachintorn, Kwong Ming Fock, Ari Fahrial Syam, Abdul Aziz Rani, Jose D. SollanoQi Zhu

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)


Objective: Guidelines on the management of antithrombotic therapy for endoscopic procedures vary among countries. Differences in the management of antithrombotic agents for endoscopic procedures between Western and Eastern countries have already been reported. However, no study has investigated the differences among Asian countries. The aim of this study was to examine the differences in the etiology of gastrointestinal bleeding and management of antithrombotic agents during endoscopic procedures between Japan and other Asian countries (OAC). Methods: Questionnaires regarding gastrointestinal bleeding in clinical practice and management of antithrombotic agents during endoscopy were distributed to members of the International Gastroenterology Consensus Symposium Study Group. We analyzed the questionnaire answers and compared the results between Japan and OAC. Results: The cause of and treatment methods for gastrointestinal bleeding differed between Japan and OAC. In Japan, the trend was to continue drugs at the time of biopsy and endoscopic therapy. Even in cases of discontinuation, the drug withdrawal period was as short as <3 days. Thrombotic complications caused by the withdrawal of antithrombotic agents were observed more frequently in Japan (34.78%) than in OAC (22.46%; p = 0.016). Conclusion: Due to differences in guidelines and complications associated with discontinuation of drugs, the antithrombotic withdrawal period in Japan tended to be shorter than that in OAC.

Original languageEnglish
Pages (from-to)97-106
Number of pages10
Issue number1
Publication statusPublished - 1 Mar 2018


  • Anticoagulants
  • Antiplatelet agents
  • Asia
  • Gastrointestinal bleeding
  • Thromboembolism


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