Quantification of 6-mercaptopurine and its metabolites in patients with acute lympoblastic leukemia using dried blood spots and UPLC-MS/MS

Keyphrases

• 5-fluorouracil (5-FU) 50%
• 5′-monophosphate 100%
• 6-mercaptopurine (6-MP) 100%
• 6-methylmercaptopurine 100%
• 6-thioguanosine 100%
• Acetonitrile-methanol 25%
• Acquity 25%
• Active Metabolite 25%
• Acute Lymphoblastic Leukemia 50%
• Acute Lympoblastic Leukemia 100%
• Amida 25%
• Analytical Separation 25%
• Bioanalysis 25%
• Calibration Curve 25%
• Dose Adjustment 25%
• Dried Blood Spot Cards 25%
• Dried Blood Spots 100%
• Erythrocytes 50%
• Formic Acid 50%
• Gradient Elution 25%
• Hepatotoxic 25%
• High Performance Liquid Chromatography-tandem Mass Spectrometry (HPLC-MS/MS) 100%
• Leukemia Patients 50%
• Linear Calibration 25%
• Mass Detection 25%
• Methanol 25%
• Mobile Phase 25%
• Phase Mixture 25%
• Therapeutic Drug Monitoring 25%
• Therapeutic Range 50%
• Treatment Dose 25%
• UPLC™ 25%

Pharmacology, Toxicology and Pharmaceutical Science

• Acetonitrile 25%
• Active Metabolite 25%
• Acute Lymphoblastic Leukemia 50%
• Fluorouracil 50%
• Formate 50%
• Hepatotoxicity 25%
• Leukemia 100%
• Mercaptopurine 100%
• Methanol 50%
• Therapeutic Drug Monitoring 25%
• Thioguanosine 100%

Biochemistry, Genetics and Molecular Biology

• Dried Blood Spot 100%
• Flow Rate 25%
• Fluorouracil 50%
• Gradient Elution 25%
• Mercaptopurine 100%
• Metabolite 100%
• Mobile Phase Composition 25%
• Tandem Mass Spectrometry 100%