Purpuric nail striae as the initial manifestation in multisystem Langerhans cell histiocytosis

Rizky Lendl Prayogo, Githa Rahmayunita, Triana Agustin, Sondang P. Sirait, Riesye Arisanty

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

Nail involvement in Langerhans cell histiocytosis (LCH) is very uncommon. We describe a 9-month-old boy with longitudinal purpuric bands, onychodystrophy, and paronychias on his fingernails and toenails, which antedated manifestations of recurrent bilateral spontaneous pneumothorax and elevated transaminases. The diagnosis of nail LCH was then confirmed by immunohistochemistry demonstrating positive S100 and CD1a staining in the epithelium of nail bed tissue. This case report affirms that nail involvement may be the initial manifestation of multisystem LCH and could portend an unfavorable prognosis.

Original languageEnglish
Pages (from-to)180-183
Number of pages4
JournalPediatric Dermatology
Volume37
Issue number1
DOIs
Publication statusPublished - 1 Jan 2020

Keywords

  • Langerhans cell histiocytosis
  • nail
  • onychodystrophy
  • purpuric striae

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