Purpuric nail striae as the initial manifestation in multisystem Langerhans cell histiocytosis

Rizky Lendl Prayogo; Githa Rahmayunita; Triana Agustin; Sondang P. Sirait; Riesye Arisanty

doi:10.1111/pde.14054

Purpuric nail striae as the initial manifestation in multisystem Langerhans cell histiocytosis

Rizky Lendl Prayogo, Githa Rahmayunita, Triana Agustin, Sondang P. Sirait, Riesye Arisanty

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

Abstract

Nail involvement in Langerhans cell histiocytosis (LCH) is very uncommon. We describe a 9-month-old boy with longitudinal purpuric bands, onychodystrophy, and paronychias on his fingernails and toenails, which antedated manifestations of recurrent bilateral spontaneous pneumothorax and elevated transaminases. The diagnosis of nail LCH was then confirmed by immunohistochemistry demonstrating positive S100 and CD1a staining in the epithelium of nail bed tissue. This case report affirms that nail involvement may be the initial manifestation of multisystem LCH and could portend an unfavorable prognosis.

Original language	English
Pages (from-to)	180-183
Number of pages	4
Journal	Pediatric Dermatology
Volume	37
Issue number	1
DOIs	https://doi.org/10.1111/pde.14054
Publication status	Published - 1 Jan 2020

Keywords

Langerhans cell histiocytosis
nail
onychodystrophy
purpuric striae

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title = "Purpuric nail striae as the initial manifestation in multisystem Langerhans cell histiocytosis",

abstract = "Nail involvement in Langerhans cell histiocytosis (LCH) is very uncommon. We describe a 9-month-old boy with longitudinal purpuric bands, onychodystrophy, and paronychias on his fingernails and toenails, which antedated manifestations of recurrent bilateral spontaneous pneumothorax and elevated transaminases. The diagnosis of nail LCH was then confirmed by immunohistochemistry demonstrating positive S100 and CD1a staining in the epithelium of nail bed tissue. This case report affirms that nail involvement may be the initial manifestation of multisystem LCH and could portend an unfavorable prognosis.",

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AU - Prayogo, Rizky Lendl

AU - Rahmayunita, Githa

AU - Agustin, Triana

AU - Sirait, Sondang P.

AU - Arisanty, Riesye

PY - 2020/1/1

Y1 - 2020/1/1

N2 - Nail involvement in Langerhans cell histiocytosis (LCH) is very uncommon. We describe a 9-month-old boy with longitudinal purpuric bands, onychodystrophy, and paronychias on his fingernails and toenails, which antedated manifestations of recurrent bilateral spontaneous pneumothorax and elevated transaminases. The diagnosis of nail LCH was then confirmed by immunohistochemistry demonstrating positive S100 and CD1a staining in the epithelium of nail bed tissue. This case report affirms that nail involvement may be the initial manifestation of multisystem LCH and could portend an unfavorable prognosis.

AB - Nail involvement in Langerhans cell histiocytosis (LCH) is very uncommon. We describe a 9-month-old boy with longitudinal purpuric bands, onychodystrophy, and paronychias on his fingernails and toenails, which antedated manifestations of recurrent bilateral spontaneous pneumothorax and elevated transaminases. The diagnosis of nail LCH was then confirmed by immunohistochemistry demonstrating positive S100 and CD1a staining in the epithelium of nail bed tissue. This case report affirms that nail involvement may be the initial manifestation of multisystem LCH and could portend an unfavorable prognosis.

KW - Langerhans cell histiocytosis

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KW - onychodystrophy

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Purpuric nail striae as the initial manifestation in multisystem Langerhans cell histiocytosis

Abstract

Keywords

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