Subjects with marijuana addiction tend to have cognitive function impairment. Auditory P300 wave, a potential objective tool in examining cognitive function, can assess cognitive function in the auditory pathway to the cortex. Cognitive function impairment can be assessed by prolonged latency and decreased amplitude. The present cross-sectional study was conducted between June and August 2012 involving 68 subjects with marijuana addiction. Cognitive function was assessed using Rey Auditory Verbal Learning Test. Subjects were assessed with an auditory P300 wave examination using both latency and amplitude. Forty subjects had cognitive function impairment; eight had abnormal P300 latency, whereas 60 (88.2%) had decreased amplitudes. There was significant correlation between P300 amplitude and cognitive function, but not between P300 latency and cognitive function. Marijuana can impair cognitive function, especially related to attention and memory deficit indicated by a decreasing P300 amplitude. However, P300 latency did not indicate a cognitive function impairment-related abnormality, which could have arisen from an improper range application developed with reference to American subjects. Overall, the results confirmed that cognitive function impairment due to marijuana addiction can be objectively revealed by decreasing P300 amplitudes. Further studies are needed to confirm appropriate range application in both adult and pediatric Indonesian populations.
|Journal||Journal of Physics: Conference Series|
|Publication status||Published - 7 Sep 2018|
|Event||2nd Physics and Technologies in Medicine and Dentistry Symposium, PTMDS 2018 - Depok, West Java, Indonesia|
Duration: 18 Jul 2018 → 18 Jul 2018