Modern foods in the world today use high-fructose sweeteners with high-fat foods increases the risk of metabolic syndrome. Fatty organs such as the renal can occur in the metabolic syndrome that causes renal tissue damage. The extract from the Acalypha indica L. plant, a traditional plant from Asia, allegedly has a protective effect against tissue damage to fatty organs such as the liver. This study aims to examine the protective effect of Acalypha indica L. extract on fatty renal in rats. Twenty-five male Sprague Dawley rats were randomly divided into 5 groups. Four treatment groups were induced with high-fructose and fat diet for 4 weeks were then treated with aquadest (control), standard gemfibrozil drug, Acalypha indica L. extract, and a combination of both drugs in each group for 4 weeks. The variables measured were the circumference of the glomerulus, tubular circumference, and tubular diameter of the renal. Significant differences (p < 0.05; 95% CI) were only found in tubular circumferential variables between rats with Acalypha indica L. therapy (146.02±3.46) and control (169.36±18.74) groups. However, combination of gemfibrozil and Acalypha indica L. extract was shown to share similar characteristics with the control (162.34±7.77 vs 169.36±18.74) group. This study indicates that protection effect of Acalypha indica L. extract was better than combination of Acalypha indica L. extract and gemfibrozil on fatty renal in rats.