Prostaglandin levels in gingival crevicular fluid in periodontitis patient with hypertension

Raditya Priharnanto, Robert Lessang, Sri Lelyati C. Masulili, Fatimah Maria Tadjoedin, Herlis Rahdewati, Pitu Wulandari, Elza Ibrahim Auerkari

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1 Citation (Scopus)


Objective: Periodontitis is an infection that involved tooth-supporting tissues by dental plaque biofilm on the tooth surface and host immune response as causal to as inflammation resolution. Prostaglandin E2 (PGE2) as an inflammatory mediator has been implicated in the pathogenesis of various chronic inflammatory diseases, including periodontitis, and as a regulator of blood pressure. This study aims to compare the levels of prostaglandin in the gingival crevicular fluid (GCF) of periodontitis patients with hypertension and non-hypertension. Methods: A total sample of 62 patients was examined and consists of 44 patients (aged 50–90 years) who were hypertension group and 18 patients (aged 30–49 years) who were non-hypertension groups as a control. Hypertension state was measured by blood pressure based on anamnesis and using sphygmomanometer mercury. The clinical sample was collected from 62 gingival crevicular fluids [GCF] of periodontal disease subject. Measurement of the clinical parameter of probing pocket depth [PD], and bleeding on probing [BOP ≥1] was included as a diagnostic requisition. The PD and clinical attachment loss [CAL] was defined as present if the PD was ≥5 mm and CAL was ≥1 mm. Prostaglandin E2 level was estimated in gingival crevicular fluid samples by using the enzyme-linked immunosorbent assay. Results: The level of PGE2 was statistically significant difference in hypertension patient compare with non-hypertension (p<0.05). There was a significant difference in PD, recession, and CAL (p<0.05). Conclusion: Higher blood pressure might be related to the potential risk of inflammation and progression periodontal disease.

Original languageEnglish
Pages (from-to)19-22
Number of pages4
JournalInternational Journal of Applied Pharmaceutics
Issue numberSpecial Issue 2
Publication statusPublished - Jul 2020


  • Hypertension
  • Inflammation
  • Periodontitis
  • Prostaglandin E


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