Propolis components and biological activities from stingless bees collected on South Sulawesi, Indonesia

Ryo Miyata, Muhamad Sahlan, Yoshinobu Ishikawa, Hiroshi Hashimoto, Sari Honda, Shigenori Kumazawa

Research output: Contribution to journalArticle

Abstract

Three new compounds, namely sulabiroins A (1) and B (2), and 2',3'-dihydro-3'-hydroxypapuanic acid (3), were isolated from the propolis of stingless bees (Tetragonula aff. biroi) collected on South Sulawesi, Indonesia. In addition, ten known compounds, (–)-papuanic acid (4), (–)-isocalolongic acid (5), isopapuanic acid (6), isocalopolyanic acid (7), glyasperin A (8), broussoflavonol F (9), (2S)-5,7-dihydroxy-4'-methoxy-8-prenylflavanone (10), isorhamnetin (11), (1'S)-2-trans,4-trans-abscisic acid (12), and (1'S)-2-cis,4-trans-abscisic acid (13) were identified. The structures of the new and known compounds were determined by spectroscopic analysis. The absolute configurations of sulabiroins A (1) and B (2) were determined by X-ray crystallography analysis and ECD calculation, respectively. The propolis from stingless bee (Tetragonula aff. biroi) collected on South Sulawesi contained compounds not present in propolis from other regions. Sulabiroin A (1) and isorhamnetin (11) were examined for xanthine oxidase (XO) inhibitory activity as one of biological activities; isorhamnetin (11) exhibited potent XO inhibitory activity, with an IC50 value of 3.9 µM.

Original languageEnglish
Pages (from-to)82-88
Number of pages7
JournalHAYATI Journal of Biosciences
Volume27
Issue number1
DOIs
Publication statusPublished - Jan 2020

Keywords

  • Chromanone
  • Indonesia
  • Podophyllotoxin derivatives
  • Propolis
  • Xanthine oxidase

Fingerprint Dive into the research topics of 'Propolis components and biological activities from stingless bees collected on South Sulawesi, Indonesia'. Together they form a unique fingerprint.

  • Cite this