Indonesia faces HIV/AIDS epidemy that is now developing tremendously and attacking mostly the young generation. HIV-AIDS has emerged and spread through behavior such as practicing free sex lifestyle and using drugs by sharing needles. The objective of this article is to review the current HIV/AIDS problems and measures carried out in Indonesia to help protect the people from disaster. The proportion of Indonesian females suffering from HIV/ AIDS had been increasing sharply, whose mostly are household mothers and transmitted sexually. The existing anti retroviral treatment is able to reduce HIV/AIDS transmission from mother to infant. The Government of Indonesian provides health services, medical treatment, nursing care as well as support without discrimination. Subsidized drugs were provided fully and continuously. PT Kimia Farma produces antiviral and has it distributed to the hospitals that serve HIV/AIDS patients. Measures to control the spread of HIV/AIDS are carried out through strengthening the knowledge of the people about HIV/AIDS and preventive action.