Prognostic factors for TB-associated uveitis in the Asia-Pacific Region: results of a modified Delphi survey

the International Ocular TB Study Group

Research output: Contribution to journalArticle

Abstract

Background: Prognostic factors for TB-associated uveitis (TBU) remain mostly unknown, due to the challenges in interpretation of patient data. We present consensus list of prognostic factors for resolution of inflammation in TBU, by experts across the Asia-Pacific region. Methods: We applied a modified Delphi technique to generate consensus on prognostic factors influencing the resolution of inflammation in TB-associated: anterior uveitis (AU), retinal vasculitis (RV), and multifocal serpiginoid choroiditis (MSC). The initial questionnaire was developed through a face-to-face meeting. Sixteen uveitis experts from eleven Asia-Pacific countries were included. A single investigator circulated the questionnaire electronically and received the responses. Participants scored each item on 4-point Likert scale, in three successive rounds. After each round, a number of items were reduced based on response, and summary of responses was provided to participants. At the end of Round 3, items were considered significant if they: (1) achieved a median ≥2, and interquartile range ≤1, and (2) ≥75% of the respondents agreed on whether the item was a positive or negative prognostic factor. Results: Forty-two putative questionnaire items were considered. At the end of Rounds 3, 4, 9, and 8 items in AU, RV, and MSC, respectively, met significance criteria. These included duration of disease, previous corticosteroid/immunosuppressive therapy, co-existent HIV, disease-specific imaging features, multidrug resistant TB, and duration of anti-TB therapy. Conclusions: Consensus were achieved on multiple ocular and systemic factors that influence resolution of inflammation in TBU. These will form the groundwork for validation in prospective clinical trials.

Original languageEnglish
JournalEye (Basingstoke)
DOIs
Publication statusAccepted/In press - 1 Jan 2020

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Uveitis
Retinal Vasculitis
Anterior Uveitis
Inflammation
Delphi Technique
Immunosuppressive Agents
Adrenal Cortex Hormones
Research Personnel
Clinical Trials
HIV
Surveys and Questionnaires
Therapeutics
Multifocal choroiditis

Cite this

@article{dd6c316713d34a719da1067a9ae3fdbb,
title = "Prognostic factors for TB-associated uveitis in the Asia-Pacific Region: results of a modified Delphi survey",
abstract = "Background: Prognostic factors for TB-associated uveitis (TBU) remain mostly unknown, due to the challenges in interpretation of patient data. We present consensus list of prognostic factors for resolution of inflammation in TBU, by experts across the Asia-Pacific region. Methods: We applied a modified Delphi technique to generate consensus on prognostic factors influencing the resolution of inflammation in TB-associated: anterior uveitis (AU), retinal vasculitis (RV), and multifocal serpiginoid choroiditis (MSC). The initial questionnaire was developed through a face-to-face meeting. Sixteen uveitis experts from eleven Asia-Pacific countries were included. A single investigator circulated the questionnaire electronically and received the responses. Participants scored each item on 4-point Likert scale, in three successive rounds. After each round, a number of items were reduced based on response, and summary of responses was provided to participants. At the end of Round 3, items were considered significant if they: (1) achieved a median ≥2, and interquartile range ≤1, and (2) ≥75{\%} of the respondents agreed on whether the item was a positive or negative prognostic factor. Results: Forty-two putative questionnaire items were considered. At the end of Rounds 3, 4, 9, and 8 items in AU, RV, and MSC, respectively, met significance criteria. These included duration of disease, previous corticosteroid/immunosuppressive therapy, co-existent HIV, disease-specific imaging features, multidrug resistant TB, and duration of anti-TB therapy. Conclusions: Consensus were achieved on multiple ocular and systemic factors that influence resolution of inflammation in TBU. These will form the groundwork for validation in prospective clinical trials.",
author = "{the International Ocular TB Study Group} and Soumyava Basu and {La Distia Nora}, Rina and Rao, {Narsing A.} and Xuejuan Jiang and Ahmad Fuady and McCluskey, {Peter J.} and Smith, {Justine R.} and Soumyava Basu and Jyotirmay Biswas and Padmamalini Mahendradas and Salil Mehta and Murthy, {Kalpana Babu} and Lukman Edwar and {La Distia Nora}, Rina and Kazuichi Murayama and Mohamed, {Shelina Oli} and Win, {May Z.A.} and Aba{\~n}o, {Jessica Marie} and Chee, {Soon Phaik} and Sheu, {Shwu Jiuan} and Somsiri Sukavatcharin and Rao, {Narsing A.}",
year = "2020",
month = "1",
day = "1",
doi = "10.1038/s41433-019-0743-1",
language = "English",
journal = "Eye",
issn = "0950-222X",
publisher = "Nature Publishing Group",

}

Prognostic factors for TB-associated uveitis in the Asia-Pacific Region : results of a modified Delphi survey. / the International Ocular TB Study Group.

In: Eye (Basingstoke), 01.01.2020.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Prognostic factors for TB-associated uveitis in the Asia-Pacific Region

T2 - results of a modified Delphi survey

AU - the International Ocular TB Study Group

AU - Basu, Soumyava

AU - La Distia Nora, Rina

AU - Rao, Narsing A.

AU - Jiang, Xuejuan

AU - Fuady, Ahmad

AU - McCluskey, Peter J.

AU - Smith, Justine R.

AU - Basu, Soumyava

AU - Biswas, Jyotirmay

AU - Mahendradas, Padmamalini

AU - Mehta, Salil

AU - Murthy, Kalpana Babu

AU - Edwar, Lukman

AU - La Distia Nora, Rina

AU - Murayama, Kazuichi

AU - Mohamed, Shelina Oli

AU - Win, May Z.A.

AU - Abaño, Jessica Marie

AU - Chee, Soon Phaik

AU - Sheu, Shwu Jiuan

AU - Sukavatcharin, Somsiri

AU - Rao, Narsing A.

PY - 2020/1/1

Y1 - 2020/1/1

N2 - Background: Prognostic factors for TB-associated uveitis (TBU) remain mostly unknown, due to the challenges in interpretation of patient data. We present consensus list of prognostic factors for resolution of inflammation in TBU, by experts across the Asia-Pacific region. Methods: We applied a modified Delphi technique to generate consensus on prognostic factors influencing the resolution of inflammation in TB-associated: anterior uveitis (AU), retinal vasculitis (RV), and multifocal serpiginoid choroiditis (MSC). The initial questionnaire was developed through a face-to-face meeting. Sixteen uveitis experts from eleven Asia-Pacific countries were included. A single investigator circulated the questionnaire electronically and received the responses. Participants scored each item on 4-point Likert scale, in three successive rounds. After each round, a number of items were reduced based on response, and summary of responses was provided to participants. At the end of Round 3, items were considered significant if they: (1) achieved a median ≥2, and interquartile range ≤1, and (2) ≥75% of the respondents agreed on whether the item was a positive or negative prognostic factor. Results: Forty-two putative questionnaire items were considered. At the end of Rounds 3, 4, 9, and 8 items in AU, RV, and MSC, respectively, met significance criteria. These included duration of disease, previous corticosteroid/immunosuppressive therapy, co-existent HIV, disease-specific imaging features, multidrug resistant TB, and duration of anti-TB therapy. Conclusions: Consensus were achieved on multiple ocular and systemic factors that influence resolution of inflammation in TBU. These will form the groundwork for validation in prospective clinical trials.

AB - Background: Prognostic factors for TB-associated uveitis (TBU) remain mostly unknown, due to the challenges in interpretation of patient data. We present consensus list of prognostic factors for resolution of inflammation in TBU, by experts across the Asia-Pacific region. Methods: We applied a modified Delphi technique to generate consensus on prognostic factors influencing the resolution of inflammation in TB-associated: anterior uveitis (AU), retinal vasculitis (RV), and multifocal serpiginoid choroiditis (MSC). The initial questionnaire was developed through a face-to-face meeting. Sixteen uveitis experts from eleven Asia-Pacific countries were included. A single investigator circulated the questionnaire electronically and received the responses. Participants scored each item on 4-point Likert scale, in three successive rounds. After each round, a number of items were reduced based on response, and summary of responses was provided to participants. At the end of Round 3, items were considered significant if they: (1) achieved a median ≥2, and interquartile range ≤1, and (2) ≥75% of the respondents agreed on whether the item was a positive or negative prognostic factor. Results: Forty-two putative questionnaire items were considered. At the end of Rounds 3, 4, 9, and 8 items in AU, RV, and MSC, respectively, met significance criteria. These included duration of disease, previous corticosteroid/immunosuppressive therapy, co-existent HIV, disease-specific imaging features, multidrug resistant TB, and duration of anti-TB therapy. Conclusions: Consensus were achieved on multiple ocular and systemic factors that influence resolution of inflammation in TBU. These will form the groundwork for validation in prospective clinical trials.

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U2 - 10.1038/s41433-019-0743-1

DO - 10.1038/s41433-019-0743-1

M3 - Article

AN - SCOPUS:85077338289

JO - Eye

JF - Eye

SN - 0950-222X

ER -