Progesterone receptor gene polymorphisms of rs1042838 and new mutation in ovarian endometriosis in Indonesian women

Asmarinah, Ririn Rahmala Febri, Aisyah Rifani, Adita Hadining Putri, R. Muharam

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Endometriosis is defined as the presence of endometrial-like tissue (glands and stroma) outside the uterus. The etiology and pathogenesis remain unclear. Recently, a number of studies have investigated genetic polymorphisms as a possible factor contributing to the development of endometriosis. In this study, we determined the association between single nucleotide polymorphisms (SNP) at rs1042838 as well as new mutation in PGR gene and ovarian endometriosis. Methods: This research is a case-control study comparing 30 women with ovarian endometriosis and 17 women without endometriosis. We used PCR-sequencing method to determine and explore the polymorphisms in PGR gene. Statistical analysis was Chi-square test, a two-tailed p value less than 0,05 was considered significant. Results: We found that there was statistically significant difference of PGR genotypes rs1042838 between ovarian endometriosis and controls, p = 0, 015. We also found there was a new mutation in PGR gene, even though there was no statistically significant. There was an association between the allele distribution rs1042838 in ovarian endometriosis and controls (p = 0, 008; OR = 5,040), but not the new mutation (p >0, 05; OR = 0,694). Conclusion: Our result suggests that the PGR gene polymorphisms may be associated with an increased risk of endometriosis.

Original languageEnglish
Pages (from-to)6906-6908
Number of pages3
JournalAdvanced Science Letters
Volume23
Issue number7
DOIs
Publication statusPublished - 1 Jul 2017

Keywords

  • Endometriosis
  • Polymorphisms
  • Progesterone Receptor Gene

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