TY - GEN
T1 - Profiles of Toxoplasma gondii Circulating Antigen and Seropositivity in HIV Patients
AU - Setia, Yulia Dwi
AU - Pawestri, Aulia Rahmi
AU - Adawiyah, Robiatul
AU - Nurhaliza, Annesya
AU - Audinugroho, Aisha
AU - Chilmi, Syahrul
AU - Anshory, Muhammad
AU - Iskandar, Agustin
N1 - Publisher Copyright:
© 2023 American Institute of Physics Inc.. All rights reserved.
PY - 2023/1/24
Y1 - 2023/1/24
N2 - Toxoplasma gondii, an obligate intracellular parasite, affects more than one-third of the world population. Although most remain asymptomatic, the infection may lead to complications in immunocompromised persons, including HIV patients. Unfortunately, due to the defective immune response, the diagnosis using antibody detection in HIV patients is tricky. Moreover, it is unpractical to differentiate current and past infections. Detection of circulating antigen (cAg) became a choice for acute toxoplasmosis. In this study, we explored the immunoprofiles of T. gondii in HJV patients in Malang. Eighty-seven serum samples were collected from HIV patients attending Saiful Anwar General Hospital in Malang, Indonesia. They were tested simultaneously for T. gondii cAg IgM, and IgG. Relevant clinical data were recorded. We reveal 6.9% (6/87) samples positive for T. gondii cAg. All samples are positive for mti-Toxoplasma IgG, while only 6.9% are positive for IgM. There is no correlation between cAg, IgM, and relevant clinical manifestations. Besides, we identify a high seroprevalence of toxoplasmosis in the HIV patients in Malang. The low cAg prevalence indicate that most patients are in the convalescent phase or had prior infections. Further studies are required to determine the validity and applicability of these methods in the immunocompromised population.
AB - Toxoplasma gondii, an obligate intracellular parasite, affects more than one-third of the world population. Although most remain asymptomatic, the infection may lead to complications in immunocompromised persons, including HIV patients. Unfortunately, due to the defective immune response, the diagnosis using antibody detection in HIV patients is tricky. Moreover, it is unpractical to differentiate current and past infections. Detection of circulating antigen (cAg) became a choice for acute toxoplasmosis. In this study, we explored the immunoprofiles of T. gondii in HJV patients in Malang. Eighty-seven serum samples were collected from HIV patients attending Saiful Anwar General Hospital in Malang, Indonesia. They were tested simultaneously for T. gondii cAg IgM, and IgG. Relevant clinical data were recorded. We reveal 6.9% (6/87) samples positive for T. gondii cAg. All samples are positive for mti-Toxoplasma IgG, while only 6.9% are positive for IgM. There is no correlation between cAg, IgM, and relevant clinical manifestations. Besides, we identify a high seroprevalence of toxoplasmosis in the HIV patients in Malang. The low cAg prevalence indicate that most patients are in the convalescent phase or had prior infections. Further studies are required to determine the validity and applicability of these methods in the immunocompromised population.
UR - http://www.scopus.com/inward/record.url?scp=85147296817&partnerID=8YFLogxK
U2 - 10.1063/5.0111510
DO - 10.1063/5.0111510
M3 - Conference contribution
AN - SCOPUS:85147296817
T3 - AIP Conference Proceedings
BT - 4th International Conference on Life Science and Technology, ICoLiST 2023
A2 - Taufiq, Ahmad
A2 - Susanto, Hendra
A2 - Wang, I. Ching
A2 - Nur, Hadi
A2 - Aziz, Muhammad
A2 - Chang, Chuang-Rung
A2 - Elbers, Gereon
A2 - Lestari, Sri Rahayu
A2 - Diantoro, Markus
A2 - Mufti, Nandang
A2 - Ng, Chen Siang
A2 - Malek, Nik Ahmad Nizam Nik
A2 - Sunaryono, null
A2 - Chiu, Yu-Hsin
A2 - Zubaidah, Siti
A2 - Aulanni'am, null
A2 - Wibowo, Indra
A2 - Handaya, Adeodatus Yuda
PB - American Institute of Physics Inc.
T2 - 4th International Conference on Life Science and Technology, ICoLiST 2023
Y2 - 31 August 2021
ER -
