Profile of pro-inflammatory cytokine in menopausal women linked with age and menopausal age

Background: The reduction on immune system correlated with elevation of pro-inflammatory cytokine and chronic inflammation in menopause may lead to appearance of menopausal symptoms such as joint pain, osteoporosis etc. Objective: To assess association between menopausal age, actual age, and profile of pro-inflammatory cytokine in menopausal women. Methods: Cross-sectional study with 56 menopause women. Blood was taken to measure the level of TNF-a, IL-4, IL-6, and IL-10 by ELISA method. Every subject was obtained baseline data and assessed of their menopausal symptoms with validated Menopause Rating Scale questionnaire. Results: Fifty six menopausal women observed, mean of TNF-a, IL-4, IL-6, and IL-10 levels are 3.96, 4.37, 2.55, 2.89 (pg/mL), respectively. Subjects age as well as menopausal age are negatively correlate with levels of IL-6 and IL-10 (p = 0.044; p = 0.40 (subjects age), p = 0.004; p = 0.038 (menopausal age) respectively). Duration of menopause did not correlate with pro-inflammatory cytokines levels (p > 005). Levels of pro-inflammatory cytokines (TNF-a, IL-4, IL-6, and IL-10) did not correlate with symptoms of menopause (p > 005). Conclusion: There was significant negative correlation between subject’s age and menopausal age with IL-6 and IL-10 levels in menopausal women. Pro-inflammatory cytokines levels do not correlate with symptoms of menopause.