Production of Nanopropolis Using High Pressure Ball Mill Homogenizer

Propolis is one of the product that produces by bees. Propolis commonly used as a supplement because it has a bioactive compound. Propolis is hydrophobic, so it is not absorbed by the body very well, that's why it needs other technologies to solve this problem. Encapsulation is one of the answers because this technology has "drug delivery systems." The purpose of this study is to look at the efficiency of coating, particle size of nanopropolis and antibacterial activity. The result of this research shows that the efficiency of propolis coatings by flavonoids is 94,71%. Particle Size Analyzer (PSA) is used to measure the particle size. The result is nanopropolis has an average diameter 75,7 nm and 83,9 nm. The antibacterial activity of propolis against Escherichia coli, Bacillus subtilis, and Staphylococcus aureus was detected but not in nanopropolis.