TY - JOUR
T1 - Probiotic treatment in children with lactose intolerance – An open labeled the one group pre-test post-test experimental study
AU - Arifin, Zainul
AU - Boediarso, Aswitha D.
AU - Tambunan, Taralan
PY - 2006
Y1 - 2006
N2 - Background Lactose intolerance is the most common disorder of
intestinal carbohydrate digestion. Probiotic that contains the cor-
rect strain in appropriate amount can be used as an alternative
dietary for lactose intolerance patients.
Objective This study was designed to describe the role of probiotic
in relieving lactose intolerance symptoms in children consumed
full-cream milk.
Methods This study was a clinical trial. Inclusion criteria was chil-
dren aged 12-14 years old, had a good nutrition and health status,
with positive breath hydrogen test (BHT) result and lactose intoler-
ance symptom(s), and their parents gave consent. Forty-two chil-
dren were included. All subjects consumed one glass (200 ml) of
full-cream milk twice a day for 21 days and recorded intolerance
symptoms. Probiotic was added from 8 th to 21 st day in their milk,
and responses of treatment were evaluated by scoring system
(based on borborigmic, flatulence, abdominal bloating, nausea and
vomiting, abdominal pain, and diarrhea symptoms). At the end of
study they were undergone second BHT examination.
Results There were decreasing mean score rates at 7 th day (pre)
13.8 (SD 5.5) compared with 7.5 (SD 3.5) at 14 th day (after) and
was statistically significant (P<0.001). Mean score rate at 7 th day
(pre) 13.8 (SD 5.5) compared with 21 st day (after) was 0.119 (SD
0.55) and was statistically significant (P<0.001). At the end of study,
only 2 subjects showed clinical signs of lactose intolerance. Thirty-
six subjects had normal BHT result at 21 st day and was statisti-
cally significant (P<0.001).
Conclusion Two weeks administration of probiotic could relieve
lactose intolerance symptoms in children consumed full-cream milk
AB - Background Lactose intolerance is the most common disorder of
intestinal carbohydrate digestion. Probiotic that contains the cor-
rect strain in appropriate amount can be used as an alternative
dietary for lactose intolerance patients.
Objective This study was designed to describe the role of probiotic
in relieving lactose intolerance symptoms in children consumed
full-cream milk.
Methods This study was a clinical trial. Inclusion criteria was chil-
dren aged 12-14 years old, had a good nutrition and health status,
with positive breath hydrogen test (BHT) result and lactose intoler-
ance symptom(s), and their parents gave consent. Forty-two chil-
dren were included. All subjects consumed one glass (200 ml) of
full-cream milk twice a day for 21 days and recorded intolerance
symptoms. Probiotic was added from 8 th to 21 st day in their milk,
and responses of treatment were evaluated by scoring system
(based on borborigmic, flatulence, abdominal bloating, nausea and
vomiting, abdominal pain, and diarrhea symptoms). At the end of
study they were undergone second BHT examination.
Results There were decreasing mean score rates at 7 th day (pre)
13.8 (SD 5.5) compared with 7.5 (SD 3.5) at 14 th day (after) and
was statistically significant (P<0.001). Mean score rate at 7 th day
(pre) 13.8 (SD 5.5) compared with 21 st day (after) was 0.119 (SD
0.55) and was statistically significant (P<0.001). At the end of study,
only 2 subjects showed clinical signs of lactose intolerance. Thirty-
six subjects had normal BHT result at 21 st day and was statisti-
cally significant (P<0.001).
Conclusion Two weeks administration of probiotic could relieve
lactose intolerance symptoms in children consumed full-cream milk
UR - https://paediatricaindonesiana.org/index.php/paediatrica-indonesiana/article/view/917
U2 - 10.14238/pi46.3.2006.139-43
DO - 10.14238/pi46.3.2006.139-43
M3 - Article
SN - 0030-9311
VL - 46
SP - 139
EP - 143
JO - Paediatrica Indonesiana
JF - Paediatrica Indonesiana
IS - 3
ER -
