TY - JOUR
T1 - Probiotic lactobacillus plantarum is 10506 supplementation increase SCFA of women with functional constipation
AU - Kusumo, Pratiwi Dyah
AU - Maulahela, Hasan
AU - Surono, Ingrid S.
AU - Soebandrio, Amin
AU - Abdullah, Murdani
AU - Utari, Amanda Pitarini
N1 - Funding Information:
We express our gratitude to this research especially to United States Agency for International Development (USAID) through the Sustainable Higher Education Research Alliance (SHERA) Program for Universitas Indonesia’s Scientific Modelling, Application, Research and Training for City-Centered Innovation and Technology (SMART CITY) Project Grant #AID-497-A-1600004, Sub Grant #IIE-00000078-UI-1, PT Ultra Jaya for supported supplementation, Puskesmas Petamburan Jakarta, Mapi Research Trust which has allowed the use of PAC-SYM, dr. Ibrahim Achmad and dr. Andy as research assistants of Gastroenterology Division, Department of Internal Medicine, Cipto Mangunkusumo Hospital Jakarta.
Publisher Copyright:
© 2019, Tehran University of Medical Science. All rights reserved.
PY - 2019/10
Y1 - 2019/10
N2 - Background and Objectives: Gut microbiota influences our health via multiple mechanisms. Microbiota produced Short Chain Fatty Acid (SCFA) as an energy to maintain gut ecosystem and physiology. Dysbiosis is correlated with SCFA imbalance which in turn resulted in physiological abnormalities in the intestine, such as functional constipation. Materials and Methods: Randomized Double-Blind Controlled Trial (RCT) was conducted on women with functional constipation (n=37) in the community of Jakarta and profile of SCFA was assessed by using GC-MS from the stool after 21 days supplementation of fermented milk (placebo and probiotic). Results: Probiotic supplementation significantly influenced acetate titer (p=0,032) marginally significant for propionate and butyrate (p=0.063 and p=0.068, respectively) and the respondent with increasing SCFA’s metabolite are higher in probiotic group compared to the respondents in placebo group. Acetate is the highest SCFA titer found in faeces samples of women with functional constipation. Conclusion: Probiotic Lactobacillus plantarum IS 10506 supplementation influenced all the SCFA parameter (acetate, propionate and butyrate).
AB - Background and Objectives: Gut microbiota influences our health via multiple mechanisms. Microbiota produced Short Chain Fatty Acid (SCFA) as an energy to maintain gut ecosystem and physiology. Dysbiosis is correlated with SCFA imbalance which in turn resulted in physiological abnormalities in the intestine, such as functional constipation. Materials and Methods: Randomized Double-Blind Controlled Trial (RCT) was conducted on women with functional constipation (n=37) in the community of Jakarta and profile of SCFA was assessed by using GC-MS from the stool after 21 days supplementation of fermented milk (placebo and probiotic). Results: Probiotic supplementation significantly influenced acetate titer (p=0,032) marginally significant for propionate and butyrate (p=0.063 and p=0.068, respectively) and the respondent with increasing SCFA’s metabolite are higher in probiotic group compared to the respondents in placebo group. Acetate is the highest SCFA titer found in faeces samples of women with functional constipation. Conclusion: Probiotic Lactobacillus plantarum IS 10506 supplementation influenced all the SCFA parameter (acetate, propionate and butyrate).
KW - Functional constipation
KW - Lactobacillus plantarum
KW - Probiotic
KW - Short chain fatty acid
UR - http://www.scopus.com/inward/record.url?scp=85075083279&partnerID=8YFLogxK
M3 - Article
AN - SCOPUS:85075083279
SN - 2008-3289
VL - 11
SP - 389
EP - 396
JO - Iranian Journal of Microbiology
JF - Iranian Journal of Microbiology
IS - 5
ER -