TY - JOUR
T1 - Proatherogenic or antiatherogenic high density lipoprotein type in acute coronary syndrome and healthy male person
AU - Kaniawati, Marita
AU - Yusuf, Irawan
AU - Bakri, Syakib
AU - Santoso, Anwar
N1 - Publisher Copyright:
© 2010, Faculty of Medicine, Universitas Indonesia. All rights reserved.
PY - 2010/11
Y1 - 2010/11
N2 - Aim: To make proatherogenic/antiatherogenic HDL type criteria using Apolipoprotein A-I (ApoA-I), Paraoxonase-1 (PON-1), Neopterin and HDL-cholesterol levels, which may be useful in clinical practice. Methods: This was a case control study recruiting 52 subjects with Acute Coronary Syndrome (ACS) and 30 control healthy subjects. HDL type was classified into antiatherogenic and proatherogenic based on the levels of ApoA-I, PON-1, Neopterin and HDL-cholesterol. Concentrations of ApoA-I was measured by immunoturbidimetry method, PON-1 was measured by colorimetric method, Neopterin was measured by ELISA, and HDL-C was determined by homogenous method. Univariate logistic regression analysis was done using ACS as a dependent variable and levels of ApoA-I, PON-1, Neopterin and HDL-cholesterol as independent variables. Proatherogenic/antiatherogenic HDL type was determined by using ApoA-I, PON-1, Neopterin and HDL-cholesterol cut offand odd ratios. Results: Patient’s age was 50.89 ± 12.63 year, HDL-C was 39.82 ± 9.84 mg/dL, Apo A-1 was 119.77 ± 32.05 mg/dL, PON-1 was 41.26 ± 18.19 kU/L, Neopterin was 16.22 ± 38.10 nmol/L. Cut offs of ApoA-I, PON-1 and Neopterin successively were 124.5 mg/dL, 40.8 kU/L, and 7.016 nmol/L. On univariate logistic regression analysis showed that OR of ApoA-I, PON-1 and Neopterin respectively were 29.759 (95% CI: 4.074 – 217.382), 1.647 (95% CI: 0.412 – 6.586), 4.317 (95% CI: 1.098 – 16.977). Using scoring system, we concluded that total score > 18 was proatherogenic HDL type, and total score < 18 was antiatherogenic HDL type. With this scoring we found 78.85% had proatherogenic HDL type in ACS population. Conclusions: Dysfunctional HDL or proatherogenic/antiatherogenic HDL type can be predicted by using ApoA-I –PON-1 – Neopterin – HDL-cholesterol scoring system. Those with score of 18 are supposed to have antiatherogenic HDL type, and those with score of > 18 were having proatherogenic HDL type.
AB - Aim: To make proatherogenic/antiatherogenic HDL type criteria using Apolipoprotein A-I (ApoA-I), Paraoxonase-1 (PON-1), Neopterin and HDL-cholesterol levels, which may be useful in clinical practice. Methods: This was a case control study recruiting 52 subjects with Acute Coronary Syndrome (ACS) and 30 control healthy subjects. HDL type was classified into antiatherogenic and proatherogenic based on the levels of ApoA-I, PON-1, Neopterin and HDL-cholesterol. Concentrations of ApoA-I was measured by immunoturbidimetry method, PON-1 was measured by colorimetric method, Neopterin was measured by ELISA, and HDL-C was determined by homogenous method. Univariate logistic regression analysis was done using ACS as a dependent variable and levels of ApoA-I, PON-1, Neopterin and HDL-cholesterol as independent variables. Proatherogenic/antiatherogenic HDL type was determined by using ApoA-I, PON-1, Neopterin and HDL-cholesterol cut offand odd ratios. Results: Patient’s age was 50.89 ± 12.63 year, HDL-C was 39.82 ± 9.84 mg/dL, Apo A-1 was 119.77 ± 32.05 mg/dL, PON-1 was 41.26 ± 18.19 kU/L, Neopterin was 16.22 ± 38.10 nmol/L. Cut offs of ApoA-I, PON-1 and Neopterin successively were 124.5 mg/dL, 40.8 kU/L, and 7.016 nmol/L. On univariate logistic regression analysis showed that OR of ApoA-I, PON-1 and Neopterin respectively were 29.759 (95% CI: 4.074 – 217.382), 1.647 (95% CI: 0.412 – 6.586), 4.317 (95% CI: 1.098 – 16.977). Using scoring system, we concluded that total score > 18 was proatherogenic HDL type, and total score < 18 was antiatherogenic HDL type. With this scoring we found 78.85% had proatherogenic HDL type in ACS population. Conclusions: Dysfunctional HDL or proatherogenic/antiatherogenic HDL type can be predicted by using ApoA-I –PON-1 – Neopterin – HDL-cholesterol scoring system. Those with score of 18 are supposed to have antiatherogenic HDL type, and those with score of > 18 were having proatherogenic HDL type.
KW - ApoliproteinA-I (ApoA-I)
KW - HDL-cholesterol
KW - Neopterin
KW - Paraoxonase-1 (PON-1)
KW - Proatherogenic/antiatherogenic HDL
UR - http://www.scopus.com/inward/record.url?scp=85008879548&partnerID=8YFLogxK
U2 - 10.13181/mji.v19i4.407
DO - 10.13181/mji.v19i4.407
M3 - Article
AN - SCOPUS:85008879548
VL - 19
SP - 228
EP - 234
JO - Medical Journal of Indonesia
JF - Medical Journal of Indonesia
SN - 0853-1773
IS - 4
ER -