Presentation, etiology, and outcome of brain infections in an Indonesian hospital: A cohort study.

D Imran, R Estiasari, K Maharani, Aegerin Hafiz Sucipto, DC Lestari, RE Yunus, E Yunihastuti, TH Karyadi, D Oei, IS Timan, D Wulandari, R Wahyuningsih, R Adawiyah, A Kurniawan, R Mulyadi, A Karuniawati, UA Jaya, D Safari, Laarhoven A van, B AlisjahbanaS Dian, L Chaidir, AR Ganiem, DN Lastri, Myint KS Aye, Crevel R van

Research output: Contribution to journalArticlepeer-review

Abstract

Little detailed knowledge is available regarding the etiology and outcome of CNS infection, particularly in HIV-infected individuals, in low-resource settings.

From January 2015 to April 2016, we prospectively included all adults with suspected CNS infection in a referral hospital in Jakarta, Indonesia. Systematic screening included HIV testing, CSF examination, and neuroimaging.

A total of 274 patients with suspected CNS infection (median age 26 years) presented after a median of 14 days with headache (77%), fever (78%), seizures (27%), or loss of consciousness (71%). HIV coinfection was common (54%), mostly newly diagnosed (30%) and advanced (median CD4 cell count 30/µL). Diagnosis was established in 167 participants (65%), including definite tuberculous meningitis (TBM) (n = 44), probable TBM (n = 48), cerebral toxoplasmosis (n = 48), cryptococcal meningitis (n = 14), herpes simplex virus/varicella-zoster virus/cytomegalovirus encephalitis (n = 10), cerebral lymphoma (n = 1), neurosyphilis (n = 1), and mucormycosis (n = 1). In-hospital mortality was 32%; 6-month mortality was 57%. The remaining survivors had either moderate or severe disability (36%) according to Glasgow Outcome Scale.

In this setting, patients with CNS infections present late with severe disease and often associated with advanced HIV infection. Tuberculosis, toxoplasmosis, and cryptococcosis are common. High mortality and long-term morbidity underline the need for service improvements and further study.
Original languageEnglish
Pages (from-to)379-388
Number of pages10
JournalNeurology: Clinical Practice
Volume8
Issue number5
DOIs
Publication statusPublished - 1 Oct 2018

Fingerprint Dive into the research topics of 'Presentation, etiology, and outcome of brain infections in an Indonesian hospital: A cohort study.'. Together they form a unique fingerprint.

Cite this