Preparation, physical characterization, and stability of Ferrous-Chitosan microcapsules using different iron sources

Noer Abyor Handayani, M. Luthfansyah, Elsa Anisa Krisanti, Sutrasno Kartohardjono, Kamarza Mulia

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

3 Citations (Scopus)

Abstract

Dietary modification, supplementation and food fortification are common strategies to alleviate iron deficiencies. Fortification of food is an effective long-term approach to improve iron status of populations. Fortification by adding iron directly to food will cause sensory problems and decrease its bioavailability. The purpose of iron encapsulation is: (1) to improve iron bioavailability, by preventing oxidation and contact with inhibitors and competitors; and (2) to disguise the rancid aroma and flavor of iron. A microcapsule formulation of two suitable iron compounds (iron II fumarate and iron II gluconate) using chitosan as a biodegradable polymer will be very important. Freeze dryer was also used for completing the iron microencapsulation process. The main objective of the present study was to prepare and characterize the iron-chitosan microcapsules. Physical characterization, i.e. encapsulation efficiency, iron loading capacity, and SEM, were also discussed in this paper. The stability of microencapsulated iron under simulated gastrointestinal conditions was also investigated, as well. Both iron sources were highly encapsulated, ranging from 71.5% to 98.5%. Furthermore, the highest ferrous fumarate and ferrous gluconate loaded were 1.9% and 4.8%, respectively. About 1.04% to 9.17% and 45.17% to 75.19% of Fe II and total Fe, were released in simulated gastric fluid for two hours and in simulated intestinal fluid for six hours, respectively.

Original languageEnglish
Title of host publicationProceedings of the 3rd International Symposium on Applied Chemistry 2017
EditorsSilvester Tursiloadi, Nino Rinaldi
PublisherAmerican Institute of Physics Inc.
ISBN (Electronic)9780735415942
DOIs
Publication statusPublished - 27 Nov 2017
Event3rd International Symposium on Applied Chemistry 2017, ISAC 2017 - Jakarta, Indonesia
Duration: 23 Oct 201724 Oct 2017

Publication series

NameAIP Conference Proceedings
Volume1904
ISSN (Print)0094-243X
ISSN (Electronic)1551-7616

Conference

Conference3rd International Symposium on Applied Chemistry 2017, ISAC 2017
Country/TerritoryIndonesia
CityJakarta
Period23/10/1724/10/17

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