Preparation of Titania-SupportedTriflic Acid Catalyst for Synthesis of 2,4,6-triarylpyridines

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Abstract

Nitrogen-containing compounds are found in nature and have an essential role in medicine. One of them is a derivative of 2,4,6-triarylpyridines, which has antibacterial, anti-inflammatory, anti-fungal, antioxidant, and anti-malarial activity. The synthesis of 2,4,6-triarylpyridines derivates was successfully carried out with the Multicomponent Reaction System (MCR) and solvent-free. 2,4,6-triarylpyridines compound derivative was synthesized using a TiO2.TfOH heterogeneous catalyst. TiO2 is the most popular catalyst because it is safe, environmentally friendly, and does not cause toxicity. In this study, 2,4,6-triarylpyridines were synthesized by MCR with benzaldehyde, acetophenone, and NH4OAc. The optimization reactions revealed the optimum conditions at a reaction time of 90 minutes, a temperature of 90 °C, and a catalyst weight of 5%. The yield percentage obtained under optimum conditions was found in 46.63 % after the compound was recrystallized using hot ethanol-the characterization of TiO2.TfOH catalysts were confirmed using FT-IR, XRD, and SEM-EDX. At the same time, the characterization of the 2,4,6-triarylpyridines compound derivate products was confirmed by TLC, FT-IR, UV-Vis, and GCMS.

Original languageEnglish
Title of host publication9th International Conference of the Indonesian Chemical Society, ICICS 2021
Subtitle of host publicationToward a Meaningful Society
EditorsLalu Rudyat Telly Savalas, Saprizal Hadisaputra
PublisherAmerican Institute of Physics Inc.
ISBN (Electronic)9780735443808
DOIs
Publication statusPublished - 18 Aug 2022
Event9th International Conference of the Indonesian Chemical Society: Toward a Meaningful Society, ICICS 2021 - Mataram-Lombok, Indonesia
Duration: 11 Aug 202113 Aug 2021

Publication series

NameAIP Conference Proceedings
Volume2638
ISSN (Print)0094-243X
ISSN (Electronic)1551-7616

Conference

Conference9th International Conference of the Indonesian Chemical Society: Toward a Meaningful Society, ICICS 2021
Country/TerritoryIndonesia
CityMataram-Lombok
Period11/08/2113/08/21

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