TY - GEN
T1 - Preparation of Titania-SupportedTriflic Acid Catalyst for Synthesis of 2,4,6-triarylpyridines
AU - Febria, Fika
AU - Cahyana, Antonius Herry
AU - Abdullah, Iman
N1 - Funding Information:
Thanks to Universitas Indonesia through HIBAH RISET FMIPA, a Grant of No. NKB 007/UN2.F3/HKP.05.00/2021 that financed this research.
Publisher Copyright:
© 2022 American Institute of Physics Inc.. All rights reserved.
PY - 2022/8/18
Y1 - 2022/8/18
N2 - Nitrogen-containing compounds are found in nature and have an essential role in medicine. One of them is a derivative of 2,4,6-triarylpyridines, which has antibacterial, anti-inflammatory, anti-fungal, antioxidant, and anti-malarial activity. The synthesis of 2,4,6-triarylpyridines derivates was successfully carried out with the Multicomponent Reaction System (MCR) and solvent-free. 2,4,6-triarylpyridines compound derivative was synthesized using a TiO2.TfOH heterogeneous catalyst. TiO2 is the most popular catalyst because it is safe, environmentally friendly, and does not cause toxicity. In this study, 2,4,6-triarylpyridines were synthesized by MCR with benzaldehyde, acetophenone, and NH4OAc. The optimization reactions revealed the optimum conditions at a reaction time of 90 minutes, a temperature of 90 °C, and a catalyst weight of 5%. The yield percentage obtained under optimum conditions was found in 46.63 % after the compound was recrystallized using hot ethanol-the characterization of TiO2.TfOH catalysts were confirmed using FT-IR, XRD, and SEM-EDX. At the same time, the characterization of the 2,4,6-triarylpyridines compound derivate products was confirmed by TLC, FT-IR, UV-Vis, and GCMS.
AB - Nitrogen-containing compounds are found in nature and have an essential role in medicine. One of them is a derivative of 2,4,6-triarylpyridines, which has antibacterial, anti-inflammatory, anti-fungal, antioxidant, and anti-malarial activity. The synthesis of 2,4,6-triarylpyridines derivates was successfully carried out with the Multicomponent Reaction System (MCR) and solvent-free. 2,4,6-triarylpyridines compound derivative was synthesized using a TiO2.TfOH heterogeneous catalyst. TiO2 is the most popular catalyst because it is safe, environmentally friendly, and does not cause toxicity. In this study, 2,4,6-triarylpyridines were synthesized by MCR with benzaldehyde, acetophenone, and NH4OAc. The optimization reactions revealed the optimum conditions at a reaction time of 90 minutes, a temperature of 90 °C, and a catalyst weight of 5%. The yield percentage obtained under optimum conditions was found in 46.63 % after the compound was recrystallized using hot ethanol-the characterization of TiO2.TfOH catalysts were confirmed using FT-IR, XRD, and SEM-EDX. At the same time, the characterization of the 2,4,6-triarylpyridines compound derivate products was confirmed by TLC, FT-IR, UV-Vis, and GCMS.
UR - http://www.scopus.com/inward/record.url?scp=85137508440&partnerID=8YFLogxK
U2 - 10.1063/5.0104320
DO - 10.1063/5.0104320
M3 - Conference contribution
AN - SCOPUS:85137508440
T3 - AIP Conference Proceedings
BT - 9th International Conference of the Indonesian Chemical Society, ICICS 2021
A2 - Savalas, Lalu Rudyat Telly
A2 - Hadisaputra, Saprizal
PB - American Institute of Physics Inc.
T2 - 9th International Conference of the Indonesian Chemical Society: Toward a Meaningful Society, ICICS 2021
Y2 - 11 August 2021 through 13 August 2021
ER -